发明授权
US07214532B2 Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof
有权
用于鉴定可用于内源基因激活的人细胞系的方法，由此鉴定的分离的人细胞系及其用途
- 专利标题： Methods for identifying human cell lines useful for endogenous gene activation, isolated human cell lines identified thereby, and uses thereof
- 专利标题（中）： 用于鉴定可用于内源基因激活的人细胞系的方法，由此鉴定的分离的人细胞系及其用途
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申请号： US10351397申请日： 2003-01-27
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公开(公告)号： US07214532B2公开(公告)日： 2007-05-08
- 发明人: Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
- 申请人： Anne Stern , Michael Brandt , Konrad Honold , Johannes Auer , Hans Koll , Reinhard Franze , Ulrich Pessara
- 申请人地址： DE Mannheim
- 专利权人： Roche Diagnostics, GmbH
- 当前专利权人： Roche Diagnostics, GmbH
- 当前专利权人地址： DE Mannheim
- 代理机构： Fulbright & Jaworski LLP
- 优先权： EP97112640 19970723; EP97121073 19971201; EP19753681 19971203
- 主分类号： C12N15/00
- IPC分类号： C12N15/00
摘要：
The invention concerns human cells which, due to an activation of the endogenous human EPO gene, are able to produce EPO in an adequate quantity and purity to enable a cost-effective production of human EPO as a pharmaceutical preparation. Furthermore the invention concerns a process for the production of such human EPO-producing cells, DNA constructs for the activation of the endogenous EPO gene in human cells as well as a process for the large-scale production of EPO in human cells.
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