发明授权
- 专利标题: Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor
- 专利标题(中): 含有相同药用的吡喃葡萄糖氧吡唑衍生物药物组合物及其中间体
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申请号: US10479083申请日: 2002-05-27
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公开(公告)号: US07217697B2公开(公告)日: 2007-05-15
- 发明人: Hiroaki Shiohara , Hideki Fujikura , Nobuhiko Fushimi , Fumiaki Ito , Masayuki Isaji
- 申请人: Hiroaki Shiohara , Hideki Fujikura , Nobuhiko Fushimi , Fumiaki Ito , Masayuki Isaji
- 申请人地址: JP Nagano
- 专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人: Kissei Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Nagano
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2001-163382 20010530
- 国际申请: PCT/JP02/05093 WO 20020527
- 国际公布: WO02/098893 WO 20021212
- 主分类号: A01N43/04
- IPC分类号: A01N43/04 ; A61K31/70 ; C07H15/00 ; C07H17/00
摘要:
The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group represented by the general formula; the other is an optionally substituted alkyl group or a cycloalkyl group; and R2 is a halogen atom, a hydroxy group, an optionally substituted alkyl group, an optionally substituted alkoxy group, an alkylthio group, a group of the general formula: -A-R3 wherein A is a single bond, an oxygen atom, a methylene group, an ethylene group, —OCH2— or —CH2O—; and R3 is a cycloalkyl group, a heterocycloalkyl group, an optionally substituted aryl group, an optionally substituted tiazolyl group or an optionally substituted pyridyl group, pharmaceutically acceptable salts thereof or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT1, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutical compositions comprising the same, pharmaceutical uses thereof and production intermediates thereof.