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    Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor
    1.
    发明授权
    Glucopyranosyloxypyrazole derivative medicinal composition containing the same medicinal use thereof and intermediate therefor 失效
    含有相同药用的吡喃葡萄糖氧吡唑衍生物药物组合物及其中间体

    公开(公告)号：US07217697B2

    公开(公告)日：2007-05-15

    申请号：US10479083

    申请日：2002-05-27

    申请人： Hiroaki Shiohara ,  Hideki Fujikura ,  Nobuhiko Fushimi ,  Fumiaki Ito ,  Masayuki Isaji

    发明人： Hiroaki Shiohara ,  Hideki Fujikura ,  Nobuhiko Fushimi ,  Fumiaki Ito ,  Masayuki Isaji

    IPC分类号： A01N43/04 ,  A61K31/70 ,  C07H15/00 ,  C07H17/00

    CPC分类号： C07D231/20 ,  C07H15/26 ,  C07H17/02

    摘要： The present invention provides glucopyranosyloxypyrazole derivatives represented by the general formula: wherein R1 is a hydrogen atom or a hydroxyalkyl group; one of Q and T is a group represented by the general formula; the other is an optionally substituted alkyl group or a cycloalkyl group; and R2 is a halogen atom, a hydroxy group, an optionally substituted alkyl group, an optionally substituted alkoxy group, an alkylthio group, a group of the general formula: -A-R3 wherein A is a single bond, an oxygen atom, a methylene group, an ethylene group, —OCH2— or —CH2O—; and R3 is a cycloalkyl group, a heterocycloalkyl group, an optionally substituted aryl group, an optionally substituted tiazolyl group or an optionally substituted pyridyl group, pharmaceutically acceptable salts thereof or prodrugs thereof, which exert an excellent inhibitory activity in human SGLT1, and therefore are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications or obesity, pharmaceutical compositions comprising the same, pharmaceutical uses thereof and production intermediates thereof.

    摘要翻译： 本发明提供由以下通式表示的吡喃葡萄糖氧吡唑衍生物：其中R 1是氢原子或羟烷基; Q和T之一是由通式表示的基团; 另一个是任选取代的烷基或环烷基; R 2是卤素原子，羟基，任意取代的烷基，任意取代的烷氧基，烷硫基，通式为-AR 3的基团， 其中A是单键，氧原子，亚甲基，亚乙基，-OCH 2 - 或-CH 2 O-; 和R 3是环烷基，杂环烷基，任选取代的芳基，任选取代的噻唑基或任选取代的吡啶基，其药学上可接受的盐或其前药，其具有优异的抑制性 因此可用作预防或治疗与糖尿病，糖尿病并发症或肥胖症等高血糖症相关的疾病的药物，其药物组合物，药物组合物及其生产中间体。

    Segmented document indexing and search
    4.
    发明授权
    Segmented document indexing and search 失效
    分段文档索引和搜索

    公开(公告)号：US06631373B1

    公开(公告)日：2003-10-07

    申请号：US09515665

    申请日：2000-02-29

    申请人： Noriko Otani ,  Yuji Ikeda ,  Takaya Ueda ,  Kenichi Fujii ,  Fumiaki Ito

    发明人： Noriko Otani ,  Yuji Ikeda ,  Takaya Ueda ,  Kenichi Fujii ,  Fumiaki Ito

    IPC分类号： G06F1730

    CPC分类号： G06F17/30911 ,  Y10S707/99935 ,  Y10S707/99943 ,  Y10S707/99945

    摘要： There is provided a text search apparatus capable of dividing a structured document such as an HTML document into segments, and presenting segments containing a given search key as the search result, thereby providing a part of the document matching the search condition as the result of search. The document is divided into segments by specified tags, and a level of association with an adjacent segment is calculated. A header is detected by a header tag, and the header information is added to the segment contained in the range of the header. Segments are divided and re-integrated according to the level of association therebetween, and indexes are prepared. A search is executed for two indexes, and the level of matching is calculated by weighting the search results for the indexes, and the search result judged according to such level of matching is stored or outputted for each segment.

    摘要翻译： 提供了一种文本搜索装置，其能够将诸如HTML文档的结构化文档划分成段，并且将包含给定搜索关键字的片段呈现为搜索结果，从而提供与搜索条件匹配的文档的一部分作为搜索结果 。 文档由指定的标签分成段，并计算与相邻段的关联度。 标题由报头标签检测，标题信息被添加到包含在标题范围内的段。 分段根据其间的关联程度进行分割和重新整合，并编制索引。 对两个索引执行搜索，并且通过对索引的搜索结果进行加权来计算匹配等级，并且根据这种匹配级别判断的搜索结果被存储或输出。

    Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs
    6.
    发明授权
    Nitrogenous fused-ring derivatives, medicinal compositions containing the derivatives, and use thereof as drugs 有权
    含氮稠环衍生物，含有衍生物的药物组合物及其作为药物的用途

    公开(公告)号：US07998975B2

    公开(公告)日：2011-08-16

    申请号：US12032411

    申请日：2008-02-15

    申请人： Nobuhiko Fushimi ,  Hirotaka Teranishi ,  Kazuo Shimizu ,  Shigeru Yonekubo ,  Fumiaki Ito ,  Masayuki Isaji

    发明人： Nobuhiko Fushimi ,  Hirotaka Teranishi ,  Kazuo Shimizu ,  Shigeru Yonekubo ,  Fumiaki Ito ,  Masayuki Isaji

    IPC分类号： A61K31/44 ,  A61K31/405 ,  A01N43/38

    CPC分类号： A61K31/7056 ,  A61K31/706 ,  C07H17/02

    摘要： The present invention provides nitrogen-containing fused-ring derivatives represented by the following general formula, or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exhibit an excellent inhibitory activity in human SGLT and are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications or obesity, in the formula R1 represent H, an optionally substituted alkyl group, an alkenyl group, etc.; R2 represent H, a halogen atom or an alkyl group; R3 and R4 represent H, OH, a halogen atom, an optionally substituted alkyl group, etc.; Y represents CH or N; Q represents alkylene, alkenylene, etc.; ring A represents an aryl group or a heteroaryl group; G represents a group represented by the following general formula (G-1) or (G-2) (in which E1 represents H, F or OH; and E2 represents H, F, a methyl group, etc.), and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.

    摘要翻译： 本发明提供由以下通式表示的含氮稠环衍生物或其药学上可接受的盐或其前药，其在人SGLT中表现出优异的抑制活性，并且可用作预防或治疗疾病的药剂 与糖尿病，餐后高血糖症，葡萄糖耐量降低，糖尿病并发症或肥胖症等高血糖相关，在式R 1中表示H，任选取代的烷基，烯基等; R2表示H，卤素原子或烷基; R3和R4代表H，OH，卤素原子，任选取代的烷基等; Y表示CH或N; Q表示亚烷基，亚烯基等; 环A表示芳基或杂芳基; G表示由以下通式（G-1）或（G-2）表示的基团（其中E1表示H，F或OH; E2表示H，F，甲基等）和药物组合物 包括它们的药物用途。

    SPEED CONTROL METHOD OF AUTOMATIC TRANSMISSION
    7.
    发明申请
    SPEED CONTROL METHOD OF AUTOMATIC TRANSMISSION 失效
    自动变速器速度控制方法

    公开(公告)号：US20100029438A1

    公开(公告)日：2010-02-04

    申请号：US12533326

    申请日：2009-07-31

    申请人： Kazutaka KOBAYASHI ,  Takeshige Miyazaki ,  Fumiaki Ito

    发明人： Kazutaka KOBAYASHI ,  Takeshige Miyazaki ,  Fumiaki Ito

    IPC分类号： F16H61/08

    CPC分类号： F16H61/0403 ,  F16H61/688 ,  F16H2306/18 ,  F16H2306/48 ,  Y10T74/19233 ,  Y10T74/1926 ,  Y10T74/19284 ,  Y10T477/69335

    摘要： A speed control method for an automatic transmission includes a first synchronizing process, in which a first clutch portion is operated to be in an engaging state in order to synchronize a first input shaft to a power source, a second synchronizing process, in which the first input shaft is synchronized to the output shaft by operating a gear train connected the first input shaft so as to be in an engaging state, after the first clutch portion is operated so as to be in the disengaging state and a torque transmission path switchover process for switching a torque transmitting path from a second input shaft to the first input shaft by operating the first clutch portion so as to be in an engaging state while the second clutch portion is operated so as to be in an disengaging state.

    摘要翻译： 一种用于自动变速器的速度控制方法包括：第一同步过程，其中第一离合器部分被操作为处于接合状态以使第一输入轴与动力源同步;第二同步过程，其中第一同步过程 输入轴通过在第一离合器部分被操作以处于分离状态之后操作连接到第一输入轴的齿轮系以处于接合状态而与输出轴同步，以及扭矩传递路径切换处理 通过在第二离合器部分被操作以处于分离状态的同时操作第一离合器部分而处于接合状态，将扭矩传递路径从第二输入轴切换到第一输入轴。

    Speech recognition system, speech recognition apparatus, and speech recognition method
    9.
    发明授权
    Speech recognition system, speech recognition apparatus, and speech recognition method 有权
    语音识别系统，语音识别装置和语音识别方法

    公开(公告)号：US07174299B2

    公开(公告)日：2007-02-06

    申请号：US09972996

    申请日：2001-10-10

    申请人： Kenichi Fujii ,  Yuji Ikeda ,  Takaya Ueda ,  Fumiaki Ito ,  Tomoyuki Shimizu

    发明人： Kenichi Fujii ,  Yuji Ikeda ,  Takaya Ueda ,  Fumiaki Ito ,  Tomoyuki Shimizu

    IPC分类号： G01L15/00

    CPC分类号： G10L15/32 ,  G10L15/30

    摘要： This invention has as its object to provide a speech recognition system to which a client and a device that provides a speech recognition process are connected, which provides a plurality of usable speech recognition means to the client, and which allows the client to explicitly switch and use the plurality of speech recognition means connected to the network. To achieve this object, a speech recognition system of this invention has speech input means for inputting speech at the client, designation means for designating one of the plurality of usable speech recognition means, and processing means for making the speech recognition means designated by the designation means recognize speech input from the speech input means.

    摘要翻译： 本发明的目的是提供一种语音识别系统，客户端和提供语音识别过程的设备连接到该语音识别系统，其向客户端提供多个可用的语音识别装置，并且允许客户机明确地切换和 使用连接到网络的多个语音识别装置。 为了实现该目的，本发明的语音识别系统具有用于在客户端输入语音的语音输入装置，用于指定多个可用语音识别装置中的一个的指定装置，以及用于通过指定来指定语音识别装置的处理装置 意味着识别来自语音输入装置的语音输入。

    Preventive or remedy for diseases caused by hyperglycemia
    10.
    发明申请
    Preventive or remedy for diseases caused by hyperglycemia 审中-公开
    预防或治疗由高血糖引起的疾病

    公开(公告)号：US20060035844A1

    公开(公告)日：2006-02-16

    申请号：US10537495

    申请日：2003-12-04

    申请人： Fumiaki Ito ,  Toshihide Shibazaki ,  Masaki Tomae ,  Nobuhiko Fushimi ,  Masayaki Isajo

    发明人： Fumiaki Ito ,  Toshihide Shibazaki ,  Masaki Tomae ,  Nobuhiko Fushimi ,  Masayaki Isajo

    IPC分类号： A61K31/70

    CPC分类号： A61K31/7056 ,  A61K31/706

    摘要： The present invention provides pharmaceutical compositions comprising as an active ingredient a selective SGLT1 inhibitor (e.g., an SGLT1 inhibitor substantially showing no GLUT2 and/or GLUT5 inhibitory effect), which have a wider range of inhibitory effect on carbohydrate absorption and a hypoglycemic effect caused by fructose ingestion at regular diets and therefore can exhibit a marked hypoglycemic effect, and which are suitable as agents for the prevention or treatment of diseases associated with hyperglycemia (e.g., diabetes, impaired glucose tolerance, diabetic complications, obesity).

    摘要翻译： 本发明提供药物组合物，其包含作为活性成分的选择性SGLT1抑制剂（例如，基本上不显示GLUT2和/或GLUT5抑制作用的SGLT1抑制剂），其具有对碳水化合物吸收的更宽范围的抑制作用和由 因此可以显示明显的降血糖作用，适合作为预防或治疗与高血糖相关疾病（如糖尿病，葡萄糖耐量减低，糖尿病并发症，肥胖症）的药剂。