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US07220751B2 Quinazoline derivatives and drugs 失效
喹唑啉衍生物和药物

Quinazoline derivatives and drugs
摘要:
The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia accompanied with a herpes zoster.The invention relates to a nociceptin receptor agonist comprising as an active ingredient a compound represented by Formula (I) or a salt thereof: wherein R1 represents a hydrogen atom or alkyl; A1 and A2 are the same or different and each represents a single bond or a divalent aliphatic hydrocarbon group; Q represents a single bond, cycloalkylene group, phenylene group or a divalent heterocyclic group; R2A and R2B are the same or different and each represents a hydrogen atom or alkyl; R3 represents an optionally substituted phenyl group or heterocyclic group; R4 and R5 are the same or different and each represents a hydrogen atom, alkyl, alkoxy, aralkyloxy, halogen, nitro, hydroxy, alkoxycarbonyl, —NR6R7 and the like.
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