发明授权
- 专利标题: Expressing gp140 fragment of primary HIV-1 isolate
- 专利标题(中): 表达主要HIV-1分离株的gp140片段
-
申请号: US09914205申请日: 2000-02-24
-
公开(公告)号: US07220826B1公开(公告)日: 2007-05-22
- 发明人: Charles D. Y. Sia , Shi-Xian Cao , Roy Persson , Benjamin Rovinski , Mark Parrington
- 申请人: Charles D. Y. Sia , Shi-Xian Cao , Roy Persson , Benjamin Rovinski , Mark Parrington
- 申请人地址: CA Toronto, Ontario
- 专利权人: Sanofi Pasteur Limited
- 当前专利权人: Sanofi Pasteur Limited
- 当前专利权人地址: CA Toronto, Ontario
- 代理机构: Sim & McBurney
- 代理商 Michael I. Stewart
- 国际申请: PCT/CA00/00190 WO 20000224
- 国际公布: WO00/50604 WO 20000831
- 主分类号: A61K38/04
- IPC分类号: A61K38/04 ; A61K38/00 ; A61K39/21 ; A61K39/12 ; A61K39/00
摘要:
A vector for eliciting an immune response to a host comprising a gene encoding the gp140 protein of the primary isolate of HIV-1, BX08, under the control of a promotor for expression of the protein in the host, specifically plasmids pCMV.gp140.BX08, pMP83, pMP84 and pMP88. Murine and human MHC class 1-restricted binding motifs contained in BX08 are identified.