Invention Grant
- Patent Title: Residual solvent extraction method and microparticles produced thereby
- Patent Title (中): 残留溶剂萃取方法和由此产生的微粒
-
Application No.: US11312371Application Date: 2005-12-21
-
Publication No.: US07223440B2Publication Date: 2007-05-29
- Inventor: Michael E. Rickey , J. Michael Ramstack , Rajesh Kumar
- Applicant: Michael E. Rickey , J. Michael Ramstack , Rajesh Kumar
- Applicant Address: US MA Cambridge
- Assignee: Alkermes, Inc.
- Current Assignee: Alkermes, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Covington & Burling LLP
- Agent Andrea G. Reister
- Main IPC: B01J13/12
- IPC: B01J13/12
Abstract:
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
Public/Granted literature
- US20060099271A1 Residual solvent extraction method and microparticles produced thereby Public/Granted day:2006-05-11
Information query
