发明授权
- 专利标题： Residual solvent extraction method and microparticles produced thereby
- 专利标题（中）： 残留溶剂萃取方法和由此产生的微粒
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申请号： US11312371申请日： 2005-12-21
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公开(公告)号： US07223440B2公开(公告)日： 2007-05-29
- 发明人: Michael E. Rickey , J. Michael Ramstack , Rajesh Kumar
- 申请人： Michael E. Rickey , J. Michael Ramstack , Rajesh Kumar
- 申请人地址： US MA Cambridge
- 专利权人： Alkermes, Inc.
- 当前专利权人： Alkermes, Inc.
- 当前专利权人地址： US MA Cambridge
- 代理机构： Covington & Burling LLP
- 代理商 Andrea G. Reister
- 主分类号： B01J13/12
- IPC分类号： B01J13/12
摘要：
Methods for preparing microparticles having reduced residual solvent levels. Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles. Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
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