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公开(公告)号:US20230310317A1
公开(公告)日:2023-10-05
申请号:US18023274
申请日:2021-08-27
Applicant: THE UNIVERSITY OF QUEENSLAND
Inventor: Harendra PAREKH , Preeti PANDEY
IPC: A61K9/06 , B01J13/12 , B01J13/00 , A61K47/32 , A61K31/192 , A61K9/19 , A61K47/26 , A61K47/10 , A61K31/58 , A61K31/12 , A61K31/337 , A61K36/185 , A61K31/355 , A61K31/593 , A61K38/13 , A61K47/36
CPC classification number: A61K9/06 , B01J13/125 , B01J13/0065 , A61K47/32 , A61K31/192 , A61K9/19 , A61K47/26 , A61K47/10 , A61K31/58 , A61K31/12 , A61K31/337 , A61K36/185 , A61K31/355 , A61K31/593 , A61K38/13 , A61K47/36 , A61K2236/333
Abstract: This invention relates to, in some aspects, a method of preparing a gel-based composition or a thermo-responsive sol-gel composition, including the steps of: (a) providing a mixture of a first aqueous solution comprising a first poloxamer and/or a first poloxamine with a solvent solution comprising a water miscible solvent and a hydrophobic therapeutic agent, wherein the water miscible solvent has a boiling point of less than 105° C. at atmospheric pressure and wherein the first aqueous solution and/or the solvent solution further comprise a surfactant; (b) substantially removing the water miscible solvent and water from the mixture in (a) to produce a micelle composition; and (c) contacting the micelle composition with a second aqueous solution comprising a second poloxamer and/or a second poloxamine to thereby prepare the thermo-responsive sol-gel composition. In other aspects, the present invention relates to a method of preparing a micelle composition, a thermo-responsive sol-gel composition or a gel-based composition for therapeutic use, and to methods of using the compositions.
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公开(公告)号:US20230182101A1
公开(公告)日:2023-06-15
申请号:US17979033
申请日:2022-11-02
Inventor: Hongmei BI , Guobin SHI , Liuchun GUO , Yingmei ZHANG
CPC classification number: B01J13/04 , B01J13/125
Abstract: Disclosed is a controllable method for preparing phospholipid micelles, including: S1, preparing small phospholipid vesicles; S2, preparing a graphene thin-layer electrode substrate, S3, incubating, and S4, electroforming phospholipid micelles. According to the present application, lamellar graphene is used as the electrode substrate according to the present application, where a phospholipid bilayer film is firstly spread on the surface of the substrate, and phospholipid micelles are controlled in terms of formation as well as formation state by a certain alternating current electric field on the surface of graphene; the developed method of the present application is unique in design, simple in operation, and has the advantages of fast formation, short preparation cycle and good controllability.
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公开(公告)号:US20230149019A1
公开(公告)日:2023-05-18
申请号:US16311574
申请日:2017-06-23
Applicant: Toshio Chiba , NIHON UNIVERSITY
Inventor: Toshio Chiba , Hiromasa Yamashita , Takashi Mochizuki , Kazuo Maruyama , Ryo Suzuki
CPC classification number: A61B17/1204 , A61B17/12136 , A61B17/12104 , B01J13/125 , A61B2017/1205 , A61B2017/00557
Abstract: Provided is a filling liquid (161) for filling a balloon (170) for a method for occluding a tubular organ, including a microcapsule (162) in which a balloon-dissolving substance that dissolves the balloon (170) is encapsulated, wherein the microcapsule is destroyable by an ultrasonic beam; and a liquid that is harmless in the tubular organ and does not dissolve the balloon. Further provided is a method for terminating a tubular organ occlusion including a step of applying an ultrasonic beam to a balloon (170) that is filled with the filling liquid (161) and occludes a tubular organ, thereby breaking the balloon (170) as a result.
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公开(公告)号:US20230015116A1
公开(公告)日:2023-01-19
申请号:US17896220
申请日:2022-08-26
Applicant: Jiangnan University
Inventor: Shaohai FU , Liping ZHANG , Jingjing LI , Chengcheng WANG , Xiaojun JIANG
Abstract: The disclosure belongs to the technical field of material science, and particularly relates to a method for preparing a high sensitivity temperature sensitive reversible color-changing microcapsule. According to the method, a series of novel fluorane dyes are designed and synthesized, the color-changing performance can be achieved without a color developing agent, the fluorane dyes are compounded with a phase change material according to a certain proportion, a series of two-component reversible temperature sensitive color-changing dyes are prepared, and then a two-component reversible thermochromic microcapsule with good color performance and color-changing response performance is prepared by adopting a solvent evaporation method. The two-component reversible thermochromic microcapsule provided by the disclosure can effectively alleviate the color lag phenomenon of a traditional three-component thermochromic capsule.
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公开(公告)号:US20220095674A1
公开(公告)日:2022-03-31
申请号:US17423588
申请日:2019-10-11
Applicant: Sunsho Pharmaceutical Co., Ltd.
Inventor: Kenichi Koyama
Abstract: [Problem] The present invention provides a capsule that is capable of suppressing volatilization of a highly volatile capsule content through the capsule shell and that is breakable.
[Solution] A breakable seamless capsule for a smoking equipment, comprising a content containing an oily ingredient and a capsule shell for encapsulating said content, wherein: the capsule shell contains a polysaccharide; the thickness of the capsule shell is 60 μm or more; the volatilization content (VC) of the content after leaving the content to stand under an environment at a temperature of 25° C. and a relative humidity of 40% for 4 hours is 3.0 wt % or more with respect to the total weight of the encapsulated content; and the crush strength per diameter of the capsule is 3-8 N/mm. In one embodiment, the crush strength per diameter of the capsule is 3.5-8 N/mm. In another embodiment, the capsule shell does not contain gelatin.-
公开(公告)号:US10556216B2
公开(公告)日:2020-02-11
申请号:US15472053
申请日:2017-03-28
Applicant: Becton, Dickinson and Company
Inventor: Oleg Guryev , Tatyana Chernenko , Marybeth Sharkey
Abstract: Methods and devices for producing a population of liposomes are provided. Aspects of the methods include applying a centrifugal force to a suspension of liposomes in a manner sufficient to pass the liposomes through a porous membrane to produce a population of liposomes. Aspects of the invention further include devices, systems and kits useful for performing the methods.
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公开(公告)号:US10413493B2
公开(公告)日:2019-09-17
申请号:US16189360
申请日:2018-11-13
Applicant: The Procter & Gamble Company
Inventor: Jonathan Robert Cetti , Jiten Odhavji Dihora , Steven Edward Witt , Eric Shane Henley
IPC: A61K8/28 , A61K8/11 , A61Q15/00 , A61K8/02 , A61K8/34 , A61K8/81 , A61K8/65 , A61K8/73 , A61K8/58 , B01J13/12 , A61K8/26 , A61K8/25 , A61K8/31 , A61K8/33 , A61K8/37 , A61K8/42 , A61K8/49 , A61K8/60 , A61K8/891 , A61K8/92
Abstract: Methods of making personal care compositions including microcapsules and methods of enhancing the efficacy of the microcapsules in said personal care compositions.
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公开(公告)号:US10117835B2
公开(公告)日:2018-11-06
申请号:US15378292
申请日:2016-12-14
Inventor: Cheng-Han Hung , Zong-Hsin Liu , Ying-Chieh Lin , Ming-Fang Tsai , Hai-Ching Tsou , Ying-Cheng Lu
IPC: A61K9/16 , B01J2/06 , B01J2/18 , B01J13/02 , B01J13/08 , B01J13/12 , B01J13/20 , B29B9/12 , B29B9/16 , B29B9/10 , B29K105/00
Abstract: A nozzle includes a nozzle body having a fluid passageway to which extension tubes are communicated. Each extension tube includes an end having an outlet port. The outlet ports are spaced from each other. An apparatus includes the nozzle, a fluid tank into which the extension tubes extends, a fluid shear device mounted in the fluid tank, and a temperature control system in which the fluid tank is mounted. A method includes filling a water phase fluid into the fluid tank. An oil phase fluid flows out of the nozzle body via the outlet ports. The water phase fluid is disturbed and flows out of the outlet ports to form semi-products of microparticles in the fluid tank. Each semi-product has an inner layer formed by the oil phase fluid and an outer layer formed by the water phase fluid. The outer layers of the semi-products are removed to form microparticles.
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公开(公告)号:US10045941B2
公开(公告)日:2018-08-14
申请号:US13786873
申请日:2013-03-06
Applicant: Pacira Pharmaceuticals, Inc.
IPC: A61K9/127 , B01D1/16 , A61K31/4458 , B01F3/08 , B01F5/10 , B01F7/00 , A61K9/48 , A61M11/00 , B01J13/04 , B01J13/12 , A61K31/445 , B01F3/04 , B01F15/06
CPC classification number: A61K9/1271 , A61K9/127 , A61K9/1277 , A61K9/4833 , A61K31/445 , A61K31/4458 , A61M11/00 , B01D1/16 , B01F3/04049 , B01F3/0807 , B01F3/088 , B01F5/104 , B01F7/0075 , B01F15/065 , B01F2015/061 , B01F2215/0032 , B01J13/043 , B01J13/125
Abstract: The present invention generally relates to the field of pharmaceutical sciences. More specifically, the present invention includes apparatus and devices for the preparation of pharmaceutical formulations containing large diameter synthetic membrane vesicles, such as multivesicular liposomes, methods for preparing such formulations, and the use of specific formulations for therapeutic treatment of subjects in need thereof. Formation and use of the pharmaceutical formulations containing large diameter synthetic membrane vesicles produced by using the apparatus and devices for therapeutic treatment of subjects in need thereof is also contemplated.
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公开(公告)号:US10005677B2
公开(公告)日:2018-06-26
申请号:US14404575
申请日:2013-05-31
Inventor: Gil Lee , Mark Platt , James O'Mahony
IPC: A61K9/51 , C01G49/02 , A61K9/50 , B01J13/04 , B01J13/12 , H01F1/00 , B01F3/08 , B01F3/22 , B01F7/00 , B01F15/02 , A61B5/055 , B01F15/06
CPC classification number: C01G49/02 , A61B5/055 , A61K9/5094 , B01F3/0811 , B01F3/0853 , B01F3/223 , B01F7/00 , B01F15/0203 , B01F2015/062 , B01J13/043 , B01J13/125 , C01P2004/61 , C01P2006/42 , H01F1/0054
Abstract: There is provided a method of producing microparticles using an emulsion based synthesis route including: Providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; Mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; Drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement. Also provided are micro particles of controllable size and morphology formed by the method.
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