A processing unit for a multiprocessor data processing system includes a store-through upper level cache, an instruction sequencing unit that fetches instructions for execution, at least one instruction execution unit that executes a store-conditional instruction to determine a store target address, a store queue that, following execution of the store-conditional instruction, buffers a corresponding store operation, sequencer logic associated with the store queue. The sequencer logic, responsive to receipt of a latency indication indicating that resolution of the store-conditional operation as passing or failing is subject to significant latency, invalidates, prior to resolution of the store-conditional operation, a cache line in the store-through upper level cache to which a load-reserve operation previously bound.