发明授权
US07229633B2 Biological bioadhesive compositions and methods of preparation and use
有权
生物生物粘附剂组合物及其制备和使用方法
- 专利标题: Biological bioadhesive compositions and methods of preparation and use
- 专利标题(中): 生物生物粘附剂组合物及其制备和使用方法
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申请号: US11003106申请日: 2004-12-04
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公开(公告)号: US07229633B2公开(公告)日: 2007-06-12
- 发明人: Sam L. Austin , Thomas E. Davis
- 申请人: Sam L. Austin , Thomas E. Davis
- 申请人地址: US TX Austin
- 专利权人: Spinal Restoration, Inc.
- 当前专利权人: Spinal Restoration, Inc.
- 当前专利权人地址: US TX Austin
- 代理机构: O'Keefe, Egan, Peterman & Enders, LLP
- 主分类号: A61F13/00
- IPC分类号: A61F13/00 ; A61K33/14 ; A61K31/56 ; A01N59/08 ; A01N45/00 ; A61M5/00
摘要:
The present invention relates generally to the preparation and use of biological tissue adhesives which rely on combining fibrinogen and thrombin. More particularly, the present invention relates to a method of preparing a fibrin sealant whereby said sealant is formed by reconstituting the fibrinogen or the thrombin component in the presence of biological and/or non-biological agents such as drugs, chemicals, and proteins. Preferably, these agents are introduced in solution, such as for example, a corticosteroid-containing solution like a betamethasone solution containing betamethasone acetate or betamethasone sodium phosphate; a triamicinolone solution; or a methylprednisolone solution. These solutions may be substituted for, or provided as a complement to, other solutions that are typically used in the preparation of fibrin sealants such as, for example, calcium chloride. The invention further relates to a novel method of using the improved fibrin sealant whereby the sealant and accompanying agent(s) are delivered directly to a critical site within the body and sealed in place due to the bio-static quality of the sealant. This provides therapeutic value to patients through prolonged presence, and optionally time-released delivery, of the specific agent(s) at the critical site.