Invention Grant
US07230008B2 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
有权
趋化因子受体活性的四氢吡喃基环戊基四氢吡啶并吡啶调节剂
- Patent Title: Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity
- Patent Title (中): 趋化因子受体活性的四氢吡喃基环戊基四氢吡啶并吡啶调节剂
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Application No.: US10923594Application Date: 2004-08-20
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Publication No.: US07230008B2Publication Date: 2007-06-12
- Inventor: Richard Jiao , Gabor Butora , Stephen D. Goble , Deodialsingh Guiadeen , Sander G. Mills , Gregori Morriello , Alexander Pasternak , Cheng Tang , Lihu Yang , Changyou Zhou , Shankaran Kothandaraman , Christopher Moyes
- Applicant: Richard Jiao , Gabor Butora , Stephen D. Goble , Deodialsingh Guiadeen , Sander G. Mills , Gregori Morriello , Alexander Pasternak , Cheng Tang , Lihu Yang , Changyou Zhou , Shankaran Kothandaraman , Christopher Moyes
- Applicant Address: US NJ Rahway
- Assignee: Merck & Co, Inc.
- Current Assignee: Merck & Co, Inc.
- Current Assignee Address: US NJ Rahway
- Agent William Krovatin; David Rubin
- Main IPC: A61K31/47
- IPC: A61K31/47 ; C07D471/02
Abstract:
The present invention is directed to methods for treating, preventing, ameliorating, controlling or reducing the risk of an inflammatory or immunoregulatory disorder or disease, which method comprises the administration to a patient of an effective amount of the compound of formula I: (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
Public/Granted literature
- US20050107422A1 Tetrahydropyranyl cyclopentyl tetrahydropyridopyridine modulators of chemokine receptor activity Public/Granted day:2005-05-19
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