Invention Grant
- Patent Title: Pyrrolotriazine inhibitors of kinases
- Patent Title (中): 吡咯并三嗪激酶抑制剂
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Application No.: US11345845Application Date: 2006-02-02
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Publication No.: US07244733B2Publication Date: 2007-07-17
- Inventor: John T. Hunt , Rajeev S. Bhide , Robert Michael Borzilleri , Ligang Qian
- Applicant: John T. Hunt , Rajeev S. Bhide , Robert Michael Borzilleri , Ligang Qian
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- Main IPC: A61K31/53
- IPC: A61K31/53 ; A61P35/00 ; A61P19/02 ; C07D487/04
Abstract:
The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, PDGFR, HER-1, HER-2, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
Public/Granted literature
- US20060128709A1 Pyrrolotriazine inhibitors of kinases Public/Granted day:2006-06-15
Information query
