发明授权
US07244734B2 Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity
失效
具有NK1拮抗活性的六氢和八氢吡啶并[1,2-a]吡嗪衍生物
![Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity](/docs/US/2007-07-17/US07244734B2/abs.jpg.600x600.jpg)
- 专利标题： Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity
- 专利标题（中）： 具有NK1拮抗活性的六氢和八氢吡啶并[1,2-a]吡嗪衍生物
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申请号： US10946176申请日： 2004-09-22
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公开(公告)号： US07244734B2公开(公告)日： 2007-07-17
- 发明人: Wouter I. Iwema Bakker , Gustaaf J. M. Van Scharrenburg , Adrianus Van Den Hoogenband , Andrew C. McCreary
- 申请人： Wouter I. Iwema Bakker , Gustaaf J. M. Van Scharrenburg , Adrianus Van Den Hoogenband , Andrew C. McCreary
- 申请人地址： NL Weesp
- 专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人： Solvay Pharmaceuticals B.V.
- 当前专利权人地址： NL Weesp
- 代理机构： Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
- 主分类号： A01N43/58
- IPC分类号： A01N43/58 ; A01N43/60 ; A61K31/50 ; A61K31/495 ; C07D401/00
![Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NK1 antagonistic activity](/abs-image/US/2007/07/17/US07244734B2/abs.jpg.150x150.jpg)
摘要：
The invention relates to hexahydro-pyrido[1,2-a]pyrazine derivatives having interesting neurokinin-NK1 receptor antagonistic activity. The invention also relates to methods for the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient, as well as to the use of these compositions for the treatment of disorders in which neurokinin receptors are involved. The invention relates to compounds represented by the general formula (1) wherein the symbols have the meanings as given in the description.
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