发明授权
- 专利标题： Nucleic acids encoding PTH functional domain conjugate peptides
- 专利标题（中）： 编码PTH功能结构域结合肽的核酸
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申请号： US11366391申请日： 2006-03-03
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公开(公告)号： US07244834B2公开(公告)日： 2007-07-17
- 发明人: Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
- 申请人： Thomas J. Gardella , Henry M. Kronenberg , John T. Potts, Jr. , Harald Jüppner
- 申请人地址： US MA Boston
- 专利权人： The General Hospital Corporation
- 当前专利权人： The General Hospital Corporation
- 当前专利权人地址： US MA Boston
- 代理机构： Sterne, Kessler, Goldstein & Fox P.L.L.C.
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07K14/635
摘要：
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and PTH(1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.
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