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公开(公告)号：US07270968B2
公开(公告)日：2007-09-18
申请号：US10344744
申请日：2001-08-14
IPC分类号： G01N33/567 , C12Q1/68 , C12N15/63 , C07H21/02 , C07H21/04
CPC分类号： C07K14/723 , C07K14/635 , G01N2333/723 , G01N2500/10 , G01N2510/00
摘要： The invention relates to a mammalian cell lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing carboxyl-terminal parathyroid hormone receptor (CPTHR) activity. The invention also relates to a method of screening for agonists or antagonists for CPTHR.
摘要翻译： 本发明涉及缺乏1型甲状旁腺激素（PTH）/甲状旁腺激素相关肽（PTHrP）受体（PTH1R）活性并含有羧基末端甲状旁腺激素受体（CPTHR）活性的哺乳动物细胞。 本发明还涉及筛选CPTHR的激动剂或拮抗剂的方法。
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公开(公告)号：US06362163B1
公开(公告)日：2002-03-26
申请号：US09635076
申请日：2000-08-09
申请人： Thomas J. Gardella , Harald Jüppner
发明人： Thomas J. Gardella , Harald Jüppner
IPC分类号： A61K3829
CPC分类号： C07K14/635 , A61K38/00
摘要： The present invention relates to novel PTHrP analogs that have been converted into potent PTH-2 receptor agonists or antagonists by the substitution of one or more amino acid residues of PTHrP to the corresponding residue(s) of PTH. A method of treating various disease states associated with altered function of the PTH-2 receptor, using these PTHrP analogs, is also described.
摘要翻译： 本发明涉及通过将PTHrP的一个或多个氨基酸残基取代成相应的PTH残基而已经转化为有效的PTH-2受体激动剂或拮抗剂的新型PTHrP类似物。 还描述了使用这些PTHrP类似物治疗与PTH-2受体功能改变相关的各种疾病状态的方法。
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3.发明授权PTH functional domain conjugate peptides, derivatives thereof and novel tethered ligand-receptor molecules 失效PTH功能结构域结合肽，其衍生物和新的束缚配体受体分子公开(公告)号：US07057012B1
公开(公告)日：2006-06-06
申请号：US09475158
申请日：1999-12-30
IPC分类号： C07K14/635 , A61K38/29
CPC分类号： C07K14/635 , A61K38/00
摘要： Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and (1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.
摘要翻译： 公开了PTH（1-34）片段的新型甲状旁腺激素（PTH）肽及其类似物，其通过以下方式组合N末端信号结构域（残基1-9）和C-末端结合结构域（残基15-31） 接头。 PTH（1-9） - （Gly）5-PTH（15-31）（PG5）和（1-9） - （Gly）7-PTH（15-31）和新型PTH受体的核酸分子和肽 被披露。 此外，公开了筛选PTH激动剂，药物组合物和治疗方法的方法。
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公开(公告)号：US06541220B1
公开(公告)日：2003-04-01
申请号：US09449632
申请日：1999-11-30
申请人： Harald Jüppner , David A. Rubin
发明人： Harald Jüppner , David A. Rubin
IPC分类号： C12N1512
CPC分类号： C07K14/461 , A61K38/00 , C07K14/723
摘要： The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.
摘要翻译： 本发明涉及从斑马鱼分离的新型甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrP）受体（PTH1R和PTH3R）。 本发明的受体与以前鉴定的甲状旁腺激素（PTH）/甲状旁腺相关蛋白（PTHrP）受体共享同源性。 提供分离的核酸分子，其编码斑马鱼PTH1R和PTH3R受体。 还提供了PTH1R和PTH3R受体多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定PTH1R和PTH3R受体活性的激动剂和拮抗剂以及诊断和治疗方法的筛选方法。
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公开(公告)号：US07244834B2
公开(公告)日：2007-07-17
申请号：US11366391
申请日：2006-03-03
IPC分类号： C07H21/04 , C07K14/635
CPC分类号： C07K14/635 , A61K38/00
摘要： Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and PTH(1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.
摘要翻译： 公开了PTH（1-34）片段的新型甲状旁腺激素（PTH）肽及其类似物，其通过以下方式组合N末端信号结构域（残基1-9）和C-末端结合结构域（残基15-31） 接头。 用于PTH（1-9） - （Gly）5-PTH（15-31）（PG5）和PTH（1-9） - （Gly）7-PTH（15-31）的核酸分子和肽和新型PTH 受体。 此外，公开了筛选PTH激动剂，药物组合物和治疗方法的方法。
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公开(公告)号：US07078487B2
公开(公告)日：2006-07-18
申请号：US10372095
申请日：2003-02-25
申请人： Harald Jüppner , David A Rubin
发明人： Harald Jüppner , David A Rubin
IPC分类号： C07K14/72 , C07K14/435
CPC分类号： C07K14/461 , A61K38/00 , C07K14/723
摘要： The present invention relates to novel parathyroid hormone (PTH) and parathyroid hormone related protein (PTHrP) receptors (PTH1R and PTH3R) isolated from zebrafish. The receptors of the present invention share homology with previously identified parathyroid hormone (PTH)/parathyroid related protein (PTHrP) receptors. Isolated nucleic acid molecules are provided encoding the zebrafish PTH1R and PTH3R receptors. PTH1R and PTH3R receptor polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of PTH1R and PTH3R receptor activity and to diagnostic and therapeutic methods.
摘要翻译： 本发明涉及从斑马鱼分离的新型甲状旁腺激素（PTH）和甲状旁腺激素相关蛋白（PTHrP）受体（PTH1R和PTH3R）。 本发明的受体与以前鉴定的甲状旁腺激素（PTH）/甲状旁腺相关蛋白（PTHrP）受体共享同源性。 提供分离的核酸分子，其编码斑马鱼PTH1R和PTH3R受体。 还提供了PTH1R和PTH3R受体多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定PTH1R和PTH3R受体活性的激动剂和拮抗剂以及诊断和治疗方法的筛选方法。
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7.发明授权Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) 有权甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物公开(公告)号：US06495662B1
公开(公告)日：2002-12-17
申请号：US09421379
申请日：1999-10-20
IPC分类号： C07K500
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing said peptides, and synthetic and recombinant methods for producing said peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
摘要翻译： 公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，以及含有所述肽的药物组合物以及用于产生所述肽的合成和重组方法。 还公开了使用含有所述肽的治疗有效的药物组合物治疗哺乳动物状况的方法，其特征在于骨量减少。 还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。 还公开了所述化合物的诊断和治疗方法。
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8.发明授权Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) 失效甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物公开(公告)号：US07985835B2
公开(公告)日：2011-07-26
申请号：US11598011
申请日：2006-11-13
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.
摘要翻译： 公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，以及含有这些肽的药物组合物，以及用于生产这些肽的合成和重组方法。 还公开了用于治疗哺乳动物病症的方法，其特征在于使用含有这种肽的治疗有效的药物组合物降低骨量。 还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。 还公开了这些化合物的诊断和治疗方法。
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9.发明授权Bioactive peptides and peptide derivatives of parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) 有权甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHrP）的生物活性肽和肽衍生物公开(公告)号：US07153951B2
公开(公告)日：2006-12-26
申请号：US10192673
申请日：2002-07-11
CPC分类号： C07K7/08 , A61K38/00 , C07K14/635
摘要： Novel parathyroid hormone peptide (PTH) and parathyroid hormone related peptide (PTHrP) or derivatives thereof which are biologically active are disclosed, as are pharmaceutical compositions containing such peptides, and synthetic and recombinant methods for producing such peptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing such peptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of such compounds.
摘要翻译： 公开了具有生物活性的新型甲状旁腺激素肽（PTH）和甲状旁腺激素相关肽（PTHrP）或其衍生物，含有这些肽的药物组合物，以及用于生产这些肽的合成和重组方法。 还公开了用于治疗哺乳动物病症的方法，其特征在于使用含有这种肽的治疗有效的药物组合物降低骨量。 还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。 还公开了这些化合物的诊断和治疗方法。
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公开(公告)号：US07022815B1
公开(公告)日：2006-04-04
申请号：US09672020
申请日：2000-09-29
CPC分类号： C07K14/635 , A61K38/00
摘要： Novel parathyroid hormone(PTH) polypeptide derivatives are disclosed, as are pharmaceutical compositions containing said polypeptides, and synthetic and recombinant methods for producing said polypeptides. Also disclosed are methods for treating mammalian conditions characterized by decreases in bone mass using therapeutically effective pharmaceutical compositions containing said polypeptides. Also disclosed are methods for screening candidate compounds of the invention for antagonistic or agonistic effects on parathyroid hormone receptor action. Also disclosed are diagnostic and therapeutic methods of said compounds.
摘要翻译： 公开了新型甲状旁腺激素（PTH）多肽衍生物，含有所述多肽的药物组合物以及用于产生所述多肽的合成和重组方法。 还公开了使用含有所述多肽的治疗有效的药物组合物治疗哺乳动物状况的方法，其特征在于骨量减少。 还公开了用于筛选本发明的候选化合物对甲状旁腺激素受体作用的拮抗作用或激动作用的方法。 还公开了所述化合物的诊断和治疗方法。
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