发明授权
- 专利标题： Amino ceramide-like compounds and therapeutic methods of use
- 专利标题（中）： 氨基神经酰胺类化合物及其治疗方法
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申请号： US11119541申请日： 2005-04-29
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公开(公告)号： US07253185B2公开(公告)日： 2007-08-07
- 发明人: James A. Shayman , David J. Harris , Craig Siegel , Carol A. Nelson , Diane P. Copeland
- 申请人： James A. Shayman , David J. Harris , Craig Siegel , Carol A. Nelson , Diane P. Copeland
- 申请人地址： US MI Ann Arbor US MA Cambridge
- 专利权人： The Regents of the University of Michigan,Genzyme Corporation
- 当前专利权人： The Regents of the University of Michigan,Genzyme Corporation
- 当前专利权人地址： US MI Ann Arbor US MA Cambridge
- 代理机构： Hamilton, Brook, Smith & Reynolds, P.C.
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; A61K31/40 ; C07D207/04 ; C07D211/06
摘要：
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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