发明授权
US07262302B2 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
失效
作为肿瘤坏死因子产生抑制剂的1-硫杂-3-氮杂 - 二苯并薁类及其制备中间体
- 专利标题： 1-thia-3-aza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
- 专利标题（中）： 作为肿瘤坏死因子产生抑制剂的1-硫杂-3-氮杂 - 二苯并薁类及其制备中间体
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申请号： US10515700申请日： 2003-05-20
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公开(公告)号： US07262302B2公开(公告)日： 2007-08-28
- 发明人: Mladen Mercep , Milan Mesic , Marina Modric , Dijana Pesic , Davor Kidemet
- 申请人： Mladen Mercep , Milan Mesic , Marina Modric , Dijana Pesic , Davor Kidemet
- 申请人地址： HR
- 专利权人： GlaxoSmithKline Istrazivacki Centar Zagreb, D.O.O.
- 当前专利权人： GlaxoSmithKline Istrazivacki Centar Zagreb, D.O.O.
- 当前专利权人地址： HR
- 代理商 J. Scott Young
- 优先权： HRP20020451A 20020523
- 国际申请： PCT/HR03/00023 WO 20030520
- 国际公布： WO03/099827 WO 20031204
- 主分类号： C07D277/60
- IPC分类号： C07D277/60 ; C07D513/02 ; C07D487/02
摘要：
The present invention relates to derivatives of 1-thia-3-aza-dibenzoazulene class, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory effects, especially to the inhibition of tumour necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.
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