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    Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules
    3.
    发明授权
    Compounds, compositions as carriers for steroid/nonsteroid anti-inflammatory; antienoplastic and antiviral active molecules 失效
    化合物，组合物作为类固醇/非类固醇抗炎剂的载体，抗肿瘤和抗病毒活性分子

    公开(公告)号：US07157433B2

    公开(公告)日：2007-01-02

    申请号：US10616046

    申请日：2003-07-08

    申请人： Mladen Mercep ,  Milan Mesic ,  Linda Tomaskovic ,  Stribor Markovic

    发明人： Mladen Mercep ,  Milan Mesic ,  Linda Tomaskovic ,  Stribor Markovic

    IPC分类号： A61K31/70 ,  C07H17/08

    CPC分类号： C07J17/00 ,  C07J43/003

    摘要： The present invention relates (a) to new compounds represented by Formula I: wherein M represents a macrolide subunit (macrolide moiety) derived from macrolide possessing the property of accumulation in inflammatory cells, V represents an anti-inflammatory steroid or nonsteroid subunit, or an antineoplastic or antiviral subunit and L represents a linking group covalently linking M and V; (b) to their pharmacologically acceptable salts, prodrugs and solvates, (c) to processes and intermediates for their preparation, and (d) to their use in the treatment of inflammatory/neoplastic/viral diseases and conditions in humans and animals.

    摘要翻译： 本发明涉及（a）由式I表示的新化合物：其中M表示衍生自具有炎症细胞积累性质的大环内酯的大环内酯亚单位（大环内酯部分），V表示抗炎类固醇或非类固醇亚基，或 抗肿瘤或抗病毒亚基，L代表共价连接M和V的连接基团; （b）其药理学上可接受的盐，前药和溶剂合物，（c）其制备方法和中间体，和（d）其用于治疗人和动物中的炎性/肿瘤/病毒性疾病和病症。

    1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof
    6.
    发明授权
    1,2-Diaza-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof 失效
    1,2-二氮杂 - 二苯并薁作为肿瘤坏死因子产生的抑制剂及其制备的中间体

    公开(公告)号：US07550498B2

    公开(公告)日：2009-06-23

    申请号：US10515709

    申请日：2003-05-20

    申请人： Mladen Mercep ,  Milan Mesic ,  Dijana Pesic

    发明人： Mladen Mercep ,  Milan Mesic ,  Dijana Pesic

    IPC分类号： A61K31/695 ,  C07D491/02

    CPC分类号： C07D495/04 ,  C07D491/04

    摘要： The present invention relates to derivatives of 1,2-diaza-dibenzoazulene, to their pharmacologically acceptable salts and solvates, to processes and intermediates for the preparation thereof as well as to their antiinflammatory actions, especially to the inhibition of tumor necrosis factor-α (TNF-α) production and the inhibition of interleukin-1 (IL-1) production as well as to their analgetic action.

    摘要翻译： 本发明涉及1,2-二氮杂 - 二苯并薁的衍生物，其药理学上可接受的盐和溶剂化物，其制备方法和中间体以及它们的抗炎作用，特别是抑制肿瘤坏死因子-α（ TNF-α）产生和白细胞介素-1（IL-1）产生的抑制以及它们的止痛作用。