An orthodontic set-up tray includes at least two sections, and each section includes at least one receptacle for receiving an orthodontic appliance. A coupling movably connects the sections together to enable relative movement between the sections. The coupling advantageously permits the overall size of the set-up tray to be reduced or enlarged as may be desired by the practitioner. Optionally, the coupling is a releasable coupling that enables the sections to be detached from one another.