发明授权
US07268142B2 Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
失效
喹唑啉和异喹啉的四氢异喹啉衍生物
- 专利标题： Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline
- 专利标题（中）： 喹唑啉和异喹啉的四氢异喹啉衍生物
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申请号： US11062133申请日： 2005-02-18
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公开(公告)号： US07268142B2公开(公告)日： 2007-09-11
- 发明人: Martin Patrick Allen , Thomas Allen Chappie , John Michael Humphrey , Spiros Liras , William Michael Whalen
- 申请人： Martin Patrick Allen , Thomas Allen Chappie , John Michael Humphrey , Spiros Liras , William Michael Whalen
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 代理商 Steve Zelson; James A. Jubinsky
- 主分类号： A61K31/517
- IPC分类号： A61K31/517 ; A61K31/4725 ; C07D239/94 ; C07D217/02
摘要：
The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.
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