发明授权
US07276498B2 Rapamycin analogues and uses thereof in the treatment of neurological disorders
失效
雷帕霉素类似物及其在神经障碍治疗中的用途
- 专利标题： Rapamycin analogues and uses thereof in the treatment of neurological disorders
- 专利标题（中）： 雷帕霉素类似物及其在神经障碍治疗中的用途
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申请号： US11300839申请日： 2005-12-15
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公开(公告)号： US07276498B2公开(公告)日： 2007-10-02
- 发明人: Edmund Idris Graziani , Kevin Pong , Jerauld Skotnicki
- 申请人： Edmund Idris Graziani , Kevin Pong , Jerauld Skotnicki
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 代理机构： Howson & Howson LLP
- 代理商 Arnold S. Milowsky
- 主分类号： C07D498/18
- IPC分类号： C07D498/18 ; A61K31/395
摘要：
The present invention provides compounds of the following structure, wherein R1, R2, R4, R4′, R6, R7, and R15 are defined above: These compounds are useful in treating neurological disorders or complications due to stroke or head injury; benign or malignant neoplastic disease, carcinomas and adenocarcinomas; proliferative disorders; and inflammatory disorders. The compounds are therefore useful as neuroprotective and neuroregenerative, anti-proliferative, and anti-inflammatory agents.