发明授权
US07279486B2 Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as ORL1-receptor antagonists
失效
α芳基或杂芳基甲基β-哌啶子基丙酸化合物作为ORL1-受体拮抗剂
- 专利标题： Alpha aryl or heteroaryl methyl beta piperidino propanoic acid compounds as ORL1-receptor antagonists
- 专利标题（中）： α芳基或杂芳基甲基β-哌啶子基丙酸化合物作为ORL1-受体拮抗剂
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申请号： US11092503申请日： 2005-03-29
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公开(公告)号： US07279486B2公开(公告)日： 2007-10-09
- 发明人: Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hiroshi Nakamura , Hiroki Koike , Yukari Matsumoto
- 申请人： Yoshinobu Hashizume , Masako Hirota , Sachiko Mihara , Hiroshi Nakamura , Hiroki Koike , Yukari Matsumoto
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 代理商 Gregg C. Benson; Frank W. Forman
- 主分类号： A61K31/438
- IPC分类号： A61K31/438 ; C07D491/107
摘要：
This invention provides the compounds of formula (I): or a pharmaceutically acceptable ester of such compound, or a pharmaceutically acceptable salt thereof, wherein R1 and R2 independently represent a hydrogen atom or the like; R3 represents an aryl group having from 6 to 10 ring atoms or the like; X represents an oxygen atom, or the like; Y represents an oxygen atom or the like; and n represents an integer 0, 1 or 2. These compounds have ORL1-receptor antagonist activity; and therefore, are useful to treat diseases or conditions such as pain, various CNS diseases etc.
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