In a method for operating an internal combustion engine in which the fuel is injected into a combustion chamber of a pre-injection and a main injection quantity, the quantity of fuel for the pre-injection, which is selected depending on the combustion location, is injected before the top dead center of the gas exchange, and the fuel for the main injection is injected synchronously with the induction of the air. The method is used in connection with internal combustion engines, in particular for passenger and commercial motor vehicles.