发明授权
US07300951B2 Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
失效
β-淀粉样蛋白产生的含氟和三氟烷基的杂环磺酰胺抑制剂及其衍生物
- 专利标题： Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
- 专利标题（中）： β-淀粉样蛋白产生的含氟和三氟烷基的杂环磺酰胺抑制剂及其衍生物
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申请号： US10810517申请日： 2004-03-26
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公开(公告)号： US07300951B2公开(公告)日： 2007-11-27
- 发明人: Anthony Frank Kreft , Lynn Resnick , Scott Christian Mayer , George Diamantidis , Derek Cecil Cole , Boyd Lynn Harrison , Minsheng Zhang , Molly Hoke , Tingzhong Wang , Rocco John Galante
- 申请人： Anthony Frank Kreft , Lynn Resnick , Scott Christian Mayer , George Diamantidis , Derek Cecil Cole , Boyd Lynn Harrison , Minsheng Zhang , Molly Hoke , Tingzhong Wang , Rocco John Galante
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 代理机构： Howson & Howson LLP
- 代理商 Rebecca R. Barrett
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; C07D333/10 ; C07D333/34
摘要：
Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y═C, or substituted diene fused to Y when Y═C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.