发明授权
- 专利标题： Intermediates for the synthesis of irbesartan
- 专利标题（中）： 用于合成厄贝沙坦的中间体
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申请号： US11348944申请日： 2006-02-06
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公开(公告)号： US07301035B2公开(公告)日： 2007-11-27
- 发明人: Gennady Nisnevich , Igor Rukhman , Boris Pertsikov , Julia Kaftanov , Ben-Zion Dolitzky
- 申请人： Gennady Nisnevich , Igor Rukhman , Boris Pertsikov , Julia Kaftanov , Ben-Zion Dolitzky
- 申请人地址： IL Petah Tiqva
- 专利权人： Teva Pharmaceutical Industries Ltd.
- 当前专利权人： Teva Pharmaceutical Industries Ltd.
- 当前专利权人地址： IL Petah Tiqva
- 代理机构： Kenyon and Kenyon LLP
- 主分类号： C07D235/02
- IPC分类号： C07D235/02
摘要：
Provided are a method of making irbesartan via a Suzuki coupling reaction and a novel intermediate, 2-butyl-3-(4′-bromobenzyl)-1,3-diazaspiro[4.4]non-1-ene-4-one, for such process. The novel process includes the step of reacting such intermediate with a protected imidazolephenylboronic acid.
公开/授权文献
- US20060128968A1 Novel synthesis of irbesartan 公开/授权日：2006-06-15
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