发明授权
US07312305B2 Tumor cytotoxicity induced by modulators of the CXCR4 receptor
有权
由CXCR4受体的调节剂诱导的肿瘤细胞毒性
- 专利标题： Tumor cytotoxicity induced by modulators of the CXCR4 receptor
- 专利标题（中）： 由CXCR4受体的调节剂诱导的肿瘤细胞毒性
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申请号： US10392324申请日： 2003-03-20
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公开(公告)号： US07312305B2公开(公告)日： 2007-12-25
- 发明人: Vincent C. Bond , James Lillard , Ming Bo Huang , Harvey Bumpers , Michael Powell
- 申请人： Vincent C. Bond , James Lillard , Ming Bo Huang , Harvey Bumpers , Michael Powell
- 申请人地址： US GA Atlanta
- 专利权人： Morehouse School of Medicine
- 当前专利权人： Morehouse School of Medicine
- 当前专利权人地址： US GA Atlanta
- 代理商 Glenna Hendricks
- 主分类号： C07K4/02
- IPC分类号： C07K4/02
摘要：
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
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