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公开(公告)号：US08669226B2
公开(公告)日：2014-03-11
申请号：US13267977
申请日：2011-10-07
IPC分类号： A61K38/10 , A61K38/04 , A61K38/00 , A61K38/17 , C07K7/00 , C07K7/06 , C07K7/08 , A61P31/04 , A61P31/00 , A01N63/00
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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2.发明授权Compositions and methods for treating aids or cancer by inhibiting the secretion of microparticles 有权通过抑制微粒分泌来治疗辅助剂或癌症的组合物和方法公开(公告)号：US08551943B2
公开(公告)日：2013-10-08
申请号：US13621597
申请日：2012-09-17
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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3.发明授权Compositions and methods for treating cancer by inhibiting the secretion of microparticles 有权通过抑制微粒分泌来治疗癌症的组合物和方法公开(公告)号：US08476237B2
公开(公告)日：2013-07-02
申请号：US13621618
申请日：2012-09-17
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. Also disclosed are polynucleotides encoding the peptides, expression vectors carrying the polynucleotides and methods for treating tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体和使用新肽治疗肿瘤的方法。
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公开(公告)号：US20130156801A1
公开(公告)日：2013-06-20
申请号：US13327244
申请日：2011-12-15
申请人： Vincent Craig BOND , Michael POWELL , Ming Bo HUANG , Syed ALI
发明人： Vincent Craig BOND , Michael POWELL , Ming Bo HUANG , Syed ALI
IPC分类号： A61K39/21 , C12N5/071 , A61P37/04 , A61K39/00 , G01N33/567 , C07K14/155 , C12P21/00 , A61K38/16
CPC分类号： C07K14/005 , A61K9/127 , A61K38/00 , A61K38/162 , A61K39/39 , A61K45/06 , A61K2039/55555 , C07K14/163 , C07K2319/055 , C07K2319/50 , C07K2319/60 , C12N15/00 , C12N2740/16322 , C12P21/02 , G01N33/543 , G01N33/566
摘要： The present application relates to methods of producing exosomes. The application also provides a method for preparing a protein composition comprising culturing an exosome-producing cell expressing a Nef-fusion protein comprising a Nef-derived peptide fused to a protein of interest; isolating exosomes from the exosome-producing cell culture; and purifying the protein of interest from the isolated exosomes. The application further discloses compositions that comprise exosomes containing the Nef-fusion protein, as well as methods of using the Nef-fusion protein and exosomes containing the Nef-fusion protein.
摘要翻译： 本申请涉及生产外来体的方法。 本申请还提供了一种制备蛋白质组合物的方法，包括培养表达融合蛋白质的Nef-融合蛋白的外来体产生细胞，所述Nef-融合蛋白包含与目的蛋白融合的Nef衍生肽; 从外来体产生细胞培养物中分离外来体; 并从分离的外来体纯化目的蛋白质。 本申请还公开了包含含有Nef-融合蛋白的外来体的组合物，以及使用Nef-融合蛋白和含有Nef-融合蛋白的外来体的方法。
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公开(公告)号：US07312305B2
公开(公告)日：2007-12-25
申请号：US10392324
申请日：2003-03-20
IPC分类号： C07K4/02
CPC分类号： A61K38/162
摘要： The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
摘要翻译： 本发明提供了通过施用Gp120蛋白或Nef蛋白或本发明的蛋白质（调节剂）的CXCR4特异性序列，例如在菌株HIV-1，HIV-2，SIV中发现的选择性杀死上皮细胞癌的方法， 或FIV CXCR4特异性Gp120序列或Nef蛋白或序列可以递送至粘膜或全身。 粘膜使用方法包括液体或颗粒形式的口服，鼻内，眼部，阴道内，直肠和/或尿道内给药。
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公开(公告)号：US20130089525A1
公开(公告)日：2013-04-11
申请号：US13267977
申请日：2011-10-07
CPC分类号： A61K38/162 , A61K38/08 , A61K45/06 , A61K47/60 , C07K7/06 , C12N7/00 , C12N2740/16032 , Y02A50/401 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要： The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
摘要翻译： 本申请公开了一种使用抗微生物组合物治疗微生物感染的方法，其包含含有至少一种VGFPV基序的抗微生物肽。
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7.发明申请COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 有权通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法公开(公告)号：US20100317566A1
公开(公告)日：2010-12-16
申请号：US12783829
申请日：2010-05-20
申请人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig BOND , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
IPC分类号： A61K38/16 , C07K7/06 , C07K7/08 , C07K14/00 , C07H21/00 , C12N15/63 , A61K38/08 , A61K31/7088 , A61P31/18 , A61P35/00 , A61K38/10
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译： 公开了抑制细胞释放微粒的新型肽。 肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。 还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。
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8.发明授权公开(公告)号：US08431530B2
公开(公告)日：2013-04-30
申请号：US12783829
申请日：2010-05-20
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
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9.发明申请公开(公告)号：US20130018002A1
公开(公告)日：2013-01-17
申请号：US13621618
申请日：2012-09-17
申请人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
发明人： Vincent Craig Bond , Michael Powell , Ming Bo Huang , Syed Ali , Andrea D. Raymond , Martin Neville Shelton , Francois Jean Villinger
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
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公开(公告)号：US07960346B2
公开(公告)日：2011-06-14
申请号：US11979492
申请日：2007-11-05
CPC分类号： A61K9/08 , A61K9/0019 , A61K9/0031 , A61K9/0034 , A61K9/0043 , A61K9/0048 , A61K9/006 , A61K31/198 , A61K31/70 , A61K38/00 , A61K38/162
摘要： The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
摘要翻译： 本发明提供了通过施用Gp120蛋白或Nef蛋白或本发明的蛋白质（调节剂）的CXCR4特异性序列，例如在菌株HIV-1，HIV-2，SIV中发现的选择性杀死上皮细胞癌的方法， 或FIV CXCR4特异性Gp120序列或Nef蛋白或序列可以递送至粘膜或全身。 粘膜使用方法包括液体或颗粒形式的口服，鼻内，眼部，阴道内，直肠和/或尿道内给药。
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