发明授权
- 专利标题: 3-phenylpropionic acid derivatives
- 专利标题(中): 3-苯基丙酸衍生物
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申请号: US11298920申请日: 2005-12-08
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公开(公告)号: US07312338B2公开(公告)日: 2007-12-25
- 发明人: Zbigniew Majka , Katarzyna Ewa Rusin , Andrzej Wojciech Sawicki , Krzysztof Kurowski , Katarzyna Joanna Matusiewicz , Tomasz Stawinski , Daniel Sulikowski , Piotr Kowalczyk
- 申请人: Zbigniew Majka , Katarzyna Ewa Rusin , Andrzej Wojciech Sawicki , Krzysztof Kurowski , Katarzyna Joanna Matusiewicz , Tomasz Stawinski , Daniel Sulikowski , Piotr Kowalczyk
- 申请人地址: PL Czosnow K/Warszawy
- 专利权人: Adamed, Sp. z.o.o.
- 当前专利权人: Adamed, Sp. z.o.o.
- 当前专利权人地址: PL Czosnow K/Warszawy
- 代理机构: Darby & Darby PC
- 优先权: PL371841 20041220
- 主分类号: A61K31/423
- IPC分类号: A61K31/423 ; C07D263/58
摘要:
The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH, N—C1-C10-alkyl, O, or S; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N—SO2-heteroaryl; R1 to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments
公开/授权文献
- US20070088061A1 New 3-phenylpropionic acid derivatives 公开/授权日:2007-04-19
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