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    3-phenylpropionic acid derivatives
    1.
    发明授权
    3-phenylpropionic acid derivatives 失效
    3-苯基丙酸衍生物

    公开(公告)号：US07919515B2

    公开(公告)日：2011-04-05

    申请号：US11740820

    申请日：2007-04-26

    申请人： Zbigniew Majka ,  Katarzyna Ewa Rusin ,  Andrzej Wojciech Sawicki ,  Krzysztof Kurowski ,  Katarzyna Joanna Matusiewicz ,  Tomasz Stawinski ,  Daniel Sulikowski

    发明人： Zbigniew Majka ,  Katarzyna Ewa Rusin ,  Andrzej Wojciech Sawicki ,  Krzysztof Kurowski ,  Katarzyna Joanna Matusiewicz ,  Tomasz Stawinski ,  Daniel Sulikowski

    IPC分类号： A61K31/423

    CPC分类号： C07D263/58 ,  C07D277/74 ,  C07D277/82 ,  C07D413/12

    摘要： The invention relates to new compounds, being 3-phenylpropionic acid derivatives of formula I wherein W represents COOH group or its bioisosters, or —COO—C1-C4-alkyl group; Y represents NH, N—C1-C10-alkyl, O, or S; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N—SO2-heteroaryl; R, to R8 each independently represent hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive; and pharmaceutically acceptable salts thereof. The compounds are the ligands of PPAR-gamma receptor and are useful as medicaments.

    摘要翻译： 本发明涉及新化合物，其为W代表COOH基团或其生物分子筛或-COO-C 1 -C 4 - 烷基的式I的3-苯基丙酸衍生物; Y表示NH，N-C 1 -C 10烷基，O或S; Z表示NH，N-C 1 -C 10 - 烷基，N-芳基，N-杂芳基，S或O; X表示O，S，NH，N-C 1 -C 10 - 烷基，N-芳基，NSO 2 -C 1 -C 10烷基，N-SO 2 - 芳基或N-SO 2 - 杂芳基; R 8至R 8各自独立地表示氢原子或说明书中定义的取代基; A如说明书中所定义; n表示0〜4的整数，包括端值; 及其药学上可接受的盐。 这些化合物是PPAR-γ受体的配体，可用作药物。

    3-phenylpropionic acid derivatives
    4.
    发明授权
    3-phenylpropionic acid derivatives 失效
    3-苯基丙酸衍生物

    公开(公告)号：US07629370B2

    公开(公告)日：2009-12-08

    申请号：US11714984

    申请日：2007-03-06

    申请人： Zbigniew Majka ,  Katarzyna Ewa Rusin ,  Dominik Daniel Kludkiewicz ,  Krzysztof Kurowski ,  Katarzyna Joanna Matusiewicz ,  Tomasz Stawinski ,  Daniel Sulikowski ,  Piotr Kowalczyk

    发明人： Zbigniew Majka ,  Katarzyna Ewa Rusin ,  Dominik Daniel Kludkiewicz ,  Krzysztof Kurowski ,  Katarzyna Joanna Matusiewicz ,  Tomasz Stawinski ,  Daniel Sulikowski ,  Piotr Kowalczyk

    IPC分类号： A61K31/426

    CPC分类号： C07D417/12 ,  C07D233/84 ,  C07D263/38 ,  C07D277/42

    摘要： The invention relates to a method of treatment and/or prophylaxis of diseases and conditions mediated by peroxysome proliferator-activated receptor gamma (PPARγ) in a mammal subject in need thereof, said method comprising administration to said mammal a compound of formula (I) or a pharmaceutically acceptable salt thereof in a therapeutically or prophylactically effective amount wherein in formula (I) W represents a COOH group or its bioisosters, or COO—C1-C4-alkyl group; Y represents NH or N—C1-C10-alkyl; Z represents NH, N—C1-C10-alkyl, N-aryl, N-heteroaryl, S, or O; X represents O, S, NH, N—C1-C10-alkyl, N-aryl, NSO2—C1-C10-alkyl, N—SO2-aryl, or N S02-heteroaryl; R1 to R6 each independently represents a hydrogen atom or a substituent defined in the description; A is as defined in the description; n represents an integer from 0 to 4, inclusive. The compounds of formula (I) are the ligands of PPAR-gamma receptor.

    摘要翻译： 本发明涉及治疗和/或预防有需要的哺乳动物受试者中由过氧化物增生物激活受体γ（PPARγ）介导的疾病和病症的方法，所述方法包括向所述哺乳动物施用式（I）化合物或 其药学上可接受的盐在治疗或预防有效量中，其中在式（I）中W表示COOH基团或其生物分子筛或COO-C 1 -C 4 - 烷基; Y表示NH或N-C 1 -C 10 - 烷基; Z表示NH，N-C 1 -C 10 - 烷基，N-芳基，N-杂芳基，S或O; X表示O，S，NH，N-C 1 -C 10 - 烷基，N-芳基，NSO 2 -C 1 -C 10烷基，N-SO 2 - 芳基或N 2 O 2 - 杂芳基; R1〜R6各自独立地表示氢原子或说明书中定义的取代基; A如说明书中所定义; n表示0〜4的整数，包括端值。 式（I）化合物是PPAR-γ受体的配体。