发明授权
- 专利标题: Small cell lung cancer associated antigens and uses therefor
- 专利标题(中): 小细胞肺癌相关抗原及其用途
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申请号: US10761169申请日: 2004-01-20
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公开(公告)号: US07314721B2公开(公告)日: 2008-01-01
- 发明人: Ali O. Gure , Elisabeth Stockert , Matthew J. Scanlan , Dirk Jager , Lloyd J. Old , Yao-Tseng Chen
- 申请人: Ali O. Gure , Elisabeth Stockert , Matthew J. Scanlan , Dirk Jager , Lloyd J. Old , Yao-Tseng Chen
- 申请人地址: US NY New York US NY New York US NY New York
- 专利权人: Ludwig Institute for Cancer Research,Memorial Sloan-Kettering Cancer Center,New York Hospital-Cornell Medical Center
- 当前专利权人: Ludwig Institute for Cancer Research,Memorial Sloan-Kettering Cancer Center,New York Hospital-Cornell Medical Center
- 当前专利权人地址: US NY New York US NY New York US NY New York
- 代理机构: Wolf, Greenfield & Sacks, P.C.
- 主分类号: G01N33/53
- IPC分类号: G01N33/53 ; C07K1/00 ; C07K16/00
摘要:
Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, among other things, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.