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发明授权
US07320785B2 Compositions and methods for modulation of DARPP-32 phosphorylation 有权
用于调节DARPP-32磷酸化的组合物和方法

Compositions and methods for modulation of DARPP-32 phosphorylation
摘要：
The present invention provides methods and compositions for modulating the phosphorylation of DARPP-32 in a serotonergic receptor intracellular signaling pathway. The invention provides methods and compositions for modulating the activities of DARPP-32, casein kinase 1 (CK1), cyclin-dependent kinase 5 (Cdk5), AMPA receptors, protein phosphatase-1 (PP-1), protein phosphatase 2C (PP2C), protein phosphatase 2B (PP2B) and/or protein phosphatase 2A (PP2A) in cells or tissues. The invention provides methods of treating serotonergic intracellular signaling pathway disorders, e.g., depression. The invention provides methods of treating dopamine-related disorders. The invention provides methods of identifying agents that modulate the activities of serotonergic receptor intracellular signaling molecules, DARPP-32, casein kinase 1, cyclin-dependent kinase 5, AMPA receptors, protein phosphatase-1, protein phosphatase 2C, protein phosphatase 2B and/or protein phosphatase 2A, for use in such treatments. The invention also provides methods of modulating phosphorylation-dependent activation of AMPA receptors for use in such treatments.
摘要（中）：

本发明提供用于调节血清素受体细胞内信号传导途径中DARPP-32的磷酸化的方法和组合物。 本发明提供了用于调节DARPP-32，酪蛋白激酶1（CK1），细胞周期蛋白依赖性激酶5（Cdk5），AMPA受体，蛋白磷酸酶-1（PP-1），蛋白磷酸酶2C（PP2C） ，蛋白磷酸酶2B（PP2B）和/或蛋白磷酸酶2A（PP2A）在细胞或组织中。 本发明提供治疗5-羟色胺能细胞内信号传导途径障碍（例如抑郁症）的方法。 本发明提供了治疗多巴胺相关疾病的方法。 本发明提供了鉴定调节血清素受体细胞内信号传导分子，DARPP-32，酪蛋白激酶1，细胞周期蛋白依赖性激酶5，AMPA受体，蛋白磷酸酶-1，蛋白磷酸酶2C，蛋白磷酸酶2B和/或 蛋白质磷酸酶2A，用于这种治疗。 本发明还提供调节用于这种治疗的AMPA受体的磷酸化依赖性活化的方法。

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