发明授权
- 专利标题: Triazole derivatives as tachykinin receptor antagonists
- 专利标题(中): 三唑衍生物作为速激肽受体拮抗剂
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申请号: US10512249申请日: 2003-04-22
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公开(公告)号: US07320994B2公开(公告)日: 2008-01-22
- 发明人: Albert Kudzovi Amegadzie , Kevin Matthew Gardinier , Erik James Hembre , Jian Eric Hong , Louis Nickolaus Jungheim , Brian Stephen Muehl , David Michael Remick , Michael Alan Robertson , Kenneth Allen Savin
- 申请人: Albert Kudzovi Amegadzie , Kevin Matthew Gardinier , Erik James Hembre , Jian Eric Hong , Louis Nickolaus Jungheim , Brian Stephen Muehl , David Michael Remick , Michael Alan Robertson , Kenneth Allen Savin
- 申请人地址: US IN Indianapolis
- 专利权人: Eli Lilly and Company
- 当前专利权人: Eli Lilly and Company
- 当前专利权人地址: US IN Indianapolis
- 代理商 Manisha A. Desai
- 国际申请: PCT/US03/10681 WO 20030422
- 国际公布: WO03/091226 WO 20031106
- 主分类号: A61K31/41
- IPC分类号: A61K31/41 ; C07D249/04
摘要:
This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermediates therefor. (I) wherein: D is a C1-C3 alkane-diyl; R1 is phenyl, which is optionally substituted with one to three substitutents independently selected from the group consisting of halo, C1-C4 alkyl, C1-C4 alkoxy, cyano, difluoromethyl, trifluoromethyl, and trifluoromethoxy; R4 is a radical selected from the group consisting of: (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH)
公开/授权文献
- US20050239786A1 Triazole derivatives as tachykinin receptor antagonists 公开/授权日:2005-10-27