Invention Grant
US07323480B2 Substituted triazoles as modulators of PPAR and methods of their preparation
有权
取代三唑作为PPAR的调节剂及其制备方法
- Patent Title: Substituted triazoles as modulators of PPAR and methods of their preparation
- Patent Title (中): 取代三唑作为PPAR的调节剂及其制备方法
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Application No.: US11137678Application Date: 2005-05-24
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Publication No.: US07323480B2Publication Date: 2008-01-29
- Inventor: Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine M. Gregoire , Vera A. Rakhmanova
- Applicant: Yan Zhu , Jingyuan Ma , Peng Cheng , Zuchun Zhao , Francine M. Gregoire , Vera A. Rakhmanova
- Applicant Address: US CA Hayward
- Assignee: Metabolex, Inc.
- Current Assignee: Metabolex, Inc.
- Current Assignee Address: US CA Hayward
- Agency: Townsend and Townsend and Crew LLP
- Main IPC: A61K31/4192
- IPC: A61K31/4192 ; A61K31/501 ; C07D249/06 ; C07D257/04
Abstract:
The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.
Public/Granted literature
- US20060014809A1 Substituted triazoles as modulators of PPAR and methods of their preparation Public/Granted day:2006-01-19
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