发明授权
- 专利标题： Processes and compounds for the preparation of substituted naphthylindole derivatives
- 专利标题（中）： 用于制备取代萘酚衍生物的方法和化合物
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申请号： US11339802申请日： 2006-01-25
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公开(公告)号： US07323483B2公开(公告)日： 2008-01-29
- 发明人: Vladimir A. Dragan , John Richard Potoski , Wayne G. McMahon , Jean Louise Helom , Xinxu Shi
- 申请人： Vladimir A. Dragan , John Richard Potoski , Wayne G. McMahon , Jean Louise Helom , Xinxu Shi
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 代理商 Mabel Ng
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; C07D257/04
摘要：
The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.