发明授权
US07332520B2 Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
有权
熔融吲哚作为二肽基肽酶抑制剂用于治疗或预防糖尿病
- 专利标题： Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes
- 专利标题（中）： 熔融吲哚作为二肽基肽酶抑制剂用于治疗或预防糖尿病
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申请号： US10558931申请日： 2004-06-02
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公开(公告)号： US07332520B2公开(公告)日： 2008-02-19
- 发明人: Scott D. Edmondson , Anthony Mastracchio , Emma R. Parmee
- 申请人： Scott D. Edmondson , Anthony Mastracchio , Emma R. Parmee
- 申请人地址： US NJ Rahway
- 专利权人： Merck & Co., Inc.
- 当前专利权人： Merck & Co., Inc.
- 当前专利权人地址： US NJ Rahway
- 代理商 Philippe L. Durette; Catherine D. Fitch
- 国际申请： PCT/US2004/017111 WO 20040602
- 国际公布： WO2004/110436 WO 20041223
- 主分类号： A61K31/403
- IPC分类号： A61K31/403 ; C07D209/82 ; C07D403/02
摘要：
The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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