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1.发明申请1,2,4-Oxadiazole Derivatives as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病的1,2,4-恶二唑衍生物公开(公告)号：US20080021009A1
公开(公告)日：2008-01-24
申请号：US11587605
申请日：2005-04-29
申请人： Jinyou Xu , Lan Wei , Anthony Mastracchio , Scott Edmondson
发明人： Jinyou Xu , Lan Wei , Anthony Mastracchio , Scott Edmondson
IPC分类号： A61K31/4245 , A61K31/397 , A61K31/4525 , A61K31/454 , A61P3/10 , C07D271/07 , C07D413/08
CPC分类号： C07D271/06 , C07D413/06 , C07D417/06
摘要： The present invention is directed to novel 1,2,4-oxadiazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的新的1,2,4-恶二唑衍生物，其可用于治疗或预防其中二肽基肽酶 - 涉及IV酶，如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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2.发明申请Fused Aminopiperidine as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权融合氨基哌啶作为二肽基肽酶-IV抑制剂治疗或预防糖尿病公开(公告)号：US20080009510A1
公开(公告)日：2008-01-10
申请号：US11667415
申请日：2005-11-22
申请人： Scott Edmondson , Anthony Mastracchio , Jason Cox
发明人： Scott Edmondson , Anthony Mastracchio , Jason Cox
IPC分类号： A61K31/44 , A61P3/00 , C07D471/00
CPC分类号： C07D471/04 , C07D471/14
摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的稠合氨基哌啶，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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3.发明授权Fused indoles as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权熔融吲哚作为二肽基肽酶抑制剂用于治疗或预防糖尿病公开(公告)号：US07332520B2
公开(公告)日：2008-02-19
申请号：US10558931
申请日：2004-06-02
IPC分类号： A61K31/403 , C07D209/82 , C07D403/02
CPC分类号： C07D209/88 , C07D209/86 , C07D403/06 , C07D417/06
摘要： The present invention is directed to fused indole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）的抑制剂的稠合吲哚衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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公开(公告)号：US20060040981A1
公开(公告)日：2006-02-23
申请号：US10536250
申请日：2003-11-19
申请人： Daniel Dube , Michel Gallant , Patrick Lacombe , Yves Girard , Dwight Macdonald , Richard Friesen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte , Annette Robichaud , Anthony Mastracchio , Helene Perrier
发明人： Daniel Dube , Michel Gallant , Patrick Lacombe , Yves Girard , Dwight Macdonald , Richard Friesen , Yves Ducharme , Bernard Cote , Marc Blouin , Evelyn Martins , Daniel Guay , Pierre Hamel , Mario Girard , Richard Frenette , Sebastien Laliberte , Annette Robichaud , Anthony Mastracchio , Helene Perrier
IPC分类号： A61K31/4709 , A61K31/47
CPC分类号： A61K31/4709 , A61K31/277 , A61K31/4375 , A61K31/44 , A61K31/47
摘要： The present invention is directed to a method of enhancing cognition in a healthy subject comprising administering a safe cognition enhancing amount of a phosphodiesterase-4 inhibitor. In particular, this invention is directed to a method of enhancing memory, learning, retention, recall, awareness and judgement in health subjects comprising administering a safe and effective amount of a phosphodiesterase-4 inhibitor.
摘要翻译： 本发明涉及增强健康受试者的认知的方法，其包括施用安全认知增加量的磷酸二酯酶-4抑制剂。 特别地，本发明涉及增加健康受试者的记忆，学习，保留，召回，意识和判断的方法，包括施用安全有效量的磷酸二酯酶-4抑制剂。
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公开(公告)号：US06410563B1
公开(公告)日：2002-06-25
申请号：US09741517
申请日：2000-12-20
申请人： Denis Deschenes , Daniel Dube , Michel Gallant , Yves Girard , Patrick Lacombe , Dwight MacDonald , Anthony Mastracchio , Helene Perrier
发明人： Denis Deschenes , Daniel Dube , Michel Gallant , Yves Girard , Patrick Lacombe , Dwight MacDonald , Anthony Mastracchio , Helene Perrier
IPC分类号： A61K314709
CPC分类号： C07D401/10 , C07D215/12 , C07D215/14 , C07D401/14 , C07D405/12 , C07D409/10 , C07D413/10 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14
摘要： Novel substituted 8-arylquinolines, wherein the aryl group at the 8-position contains a substituent substituted-alkenyl group, are PDE4 inhibitors.
摘要翻译： 新的取代的8-芳基喹啉，其中8位的芳基含有取代的取代的烯基，是PDE4抑制剂。
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6.发明申请Fused Aminopiperidines as Dipeptidyl Peptidase-4 Inhibitors for the Treatment or Prevention of Diabetes 有权融合氨基哌啶作为二肽基肽酶-4抑制剂治疗或预防糖尿病公开(公告)号：US20090233936A1
公开(公告)日：2009-09-17
申请号：US12085797
申请日：2006-12-08
IPC分类号： A61K31/4985 , C07D471/12 , A61K31/4375 , C07D487/12 , A61K31/519 , A61K31/5025 , A61P3/10
CPC分类号： C07D471/14
摘要： The present invention is directed to novel substituted fused aminopiperidines of structural formula (I) which are inhibitors of the dipeptidyl peptidase-4 enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-4 enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-4 enzyme is involved.
摘要翻译： 本发明涉及结构式（I）的新型取代的稠合氨基哌啶，其是二肽基肽酶-4酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-4酶的疾病，例如 糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-4酶的疾病中的用途。
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7.发明申请Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes 有权环己基甘氨酸衍生物作为二肽基肽酶抑制剂用于治疗或预防糖尿病公开(公告)号：US20070021477A1
公开(公告)日：2007-01-25
申请号：US10560771
申请日：2004-06-10
IPC分类号： A61K31/428 , C07D417/02
CPC分类号： C07D417/06 , C07D403/06 , C07D413/06
摘要： The present invention is directed to novel cyclohexylglycine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DP-IV抑制剂”）抑制剂的新型环己基甘氨酸衍生物，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如 作为糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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公开(公告)号：US06919353B2
公开(公告)日：2005-07-19
申请号：US10478791
申请日：2002-06-26
申请人： Daniel Dube , Yves Girard , Dwight MacDonald , Anthony Mastracchio , Michel Gallant , Patrick Lacombe , Denis Deschenes
发明人： Daniel Dube , Yves Girard , Dwight MacDonald , Anthony Mastracchio , Michel Gallant , Patrick Lacombe , Denis Deschenes
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/675 , A61K45/00 , A61P1/00 , A61P1/04 , A61P7/00 , A61P7/12 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P11/08 , A61P11/14 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/24 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/06 , A61P37/08 , A61P39/02 , A61P43/00 , C07D215/12 , C07D215/14 , C07D401/08 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/10 , C07D405/14 , C07D413/08 , C07D413/10 , C07D417/08 , C07D417/10 , C07D417/12 , C07F9/60 , C07F9/6571 , C07F9/6574
CPC分类号： C07D401/08 , C07D215/12 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/08 , C07D405/14 , C07D413/08 , C07D417/08 , C07D417/12 , C07F9/60 , C07F9/657181
摘要： 8-arylquinolines of formula (I) wherein the aryl group at the 8-position contains a meta two atom bridge to an optionally substituted phenyl or pyridyl group, are PDE4 inhibitors useful to treat asthma, chronic bronchitis, chronic obstructive pulmonary disease, arthritis, respiratory distress syndrome, allergic rhinitis, neurogenic inflammation, pain, rheumatoid arthritis, and other diseases. R1-R7 and Ar are as in claim 1.
摘要翻译： 式（I）的8-芳基喹啉，其中8位上的芳基含有任选取代的苯基或吡啶基的间二原子桥，是可用于治疗哮喘，慢性支气管炎，慢性阻塞性肺病，关节炎的PDE4抑制剂， 呼吸窘迫综合征，过敏性鼻炎，神经源性炎症，疼痛，类风湿性关节炎等疾病。 R 1〜R 7和Ar如权利要求1所述。
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9.发明授权Fused aminopiperidines as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes 有权作为二肽基肽酶-IV抑制剂的熔融氨基哌啶用于治疗或预防糖尿病公开(公告)号：US07718667B2
公开(公告)日：2010-05-18
申请号：US11667415
申请日：2005-11-22
IPC分类号： A61K31/437 , C07D471/02
CPC分类号： C07D471/04 , C07D471/14
摘要： The present invention is directed to novel substituted fused aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DPP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及作为二肽基肽酶-IV酶（“DPP-IV抑制剂”）的抑制剂的新型取代的稠合氨基哌啶，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病， 如糖尿病，特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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10.发明申请Aminocyclohexanes as Dipeptidyl Peptidase-IV Inhibitors for the Treatment or Prevention of Diabetes 有权氨基环己烷作为二肽基肽酶-IV抑制剂用于治疗或预防糖尿病公开(公告)号：US20090270467A1
公开(公告)日：2009-10-29
申请号：US12086362
申请日：2007-01-19
申请人： Tesfaye Biftu , Jason Cox , Danqing Feng , Anthony Mastracchio , Xiaoxia Qian , Ann E. Weber
发明人： Tesfaye Biftu , Jason Cox , Danqing Feng , Anthony Mastracchio , Xiaoxia Qian , Ann E. Weber
IPC分类号： A61K31/4162 , C07D487/04 , C07D513/04 , C07D498/04 , C07D491/048 , C07D495/04 , A61K31/429 , A61K31/4188 , A61K31/424 , A61K31/407 , A61P3/00
CPC分类号： C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention is directed to novel substituted aminocyclohexanes of structural formula (I) which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
摘要翻译： 本发明涉及结构式（I）的取代氨基环己烷，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病 特别是2型糖尿病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。
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