发明授权
- 专利标题： Pyridazine derivatives and their use as therapeutic agents
- 专利标题（中）： 哒嗪衍生物及其作为治疗剂的用途
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申请号： US10901563申请日： 2004-07-29
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公开(公告)号： US07335658B2公开(公告)日： 2008-02-26
- 发明人: Nagasree Chakka , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Shifeng Liu , Vandna Raina , Shaoyi Sun , Serguei Sviridov , Michael D Winther , Zaihui Zhang , Melwyn Abreo , Mark W Holladay , Wenbao Li , Sengen Sun , Chi Tu , Heinz W Gschwend
- 申请人： Nagasree Chakka , Mikhail Chafeev , Sultan Chowdhury , Jian-Min Fu , Duanjie Hou , Rajender Kamboj , Vishnumurthy Kodumuru , Shifeng Liu , Vandna Raina , Shaoyi Sun , Serguei Sviridov , Michael D Winther , Zaihui Zhang , Melwyn Abreo , Mark W Holladay , Wenbao Li , Sengen Sun , Chi Tu , Heinz W Gschwend
- 申请人地址： CA Burnaby, British Columbia
- 专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人地址： CA Burnaby, British Columbia
- 代理机构： Osha Liang LLP
- 主分类号： C07D403/04
- IPC分类号： C07D403/04 ; C07D403/14 ; A61K31/497
摘要：
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, W, V, R2, R3, R4, R5, R6, R6a, R7, R7a, R8, R8a, R9 and R9a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.