发明授权
US07335772B2 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
失效
1H-咪唑并[4,5-c]喹啉-4-氰基和1H-咪唑并[4,5-c]喹啉-4-甲酰胺中间体
![1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates](/docs/US/2008-02-26/US07335772B2/abs.jpg.600x600.jpg)
- 专利标题： 1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates
- 专利标题（中）： 1H-咪唑并[4,5-c]喹啉-4-氰基和1H-咪唑并[4,5-c]喹啉-4-甲酰胺中间体
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申请号： US11008846申请日： 2004-12-09
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公开(公告)号： US07335772B2公开(公告)日： 2008-02-26
- 发明人: Valeriano Merli , Silvia Mantovani , Stefano Bianchi
- 申请人： Valeriano Merli , Silvia Mantovani , Stefano Bianchi
- 申请人地址： HU Debrecen
- 专利权人： TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság
- 当前专利权人： TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság
- 当前专利权人地址： HU Debrecen
- 代理机构： Kenyon & Kenyon LLP
- 主分类号： C07D471/14
- IPC分类号： C07D471/14 ; A61K31/437
![1H-imidazo [4,5-c] quinolin-4-cyano and 1H-imidazo [4,5-c] quinolin-4-carboxamide intermediates](/abs-image/US/2008/02/26/US07335772B2/abs.jpg.150x150.jpg)
摘要：
The invention relates to a process for the synthesis of 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates useful in preparing 1H-imidazo[4,5-C]quinoline 4-amines, a process for preparing 1H-imidazo[4,5-C]quinoline 4-amines using such intermediates; and, to the 1H-imidazo[4,5-c]quinoline 4-cyano and 1H-imidazo[4,5-c]quinoline 4-carboxamide intermediates. More particularly, the invention relates to a process for the preparation of 1-isobutyl-1H-imidazo[4,5-C]quinoline 4-amine (Imiquimod) using two intermediates, 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-cyano and 1-isobutyl-1H-imidazo[4,5-c]quinoline 4-carboxamide, and to the said intermediates.
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