-
公开(公告)号：US09874295B2
公开(公告)日：2018-01-23
申请号：US13978858
申请日：2012-01-26
摘要： A pipe-laying vessel including a pipe-laying tower extending upwardly from the vessel, the vessel including a welding station for joining a new pipestring to an end of the pipeline held by the tower, a clamp assembly on the tower for engaging a pipestring with a lower end adjacent to the end of the pipeline held by the tower and with the pipestring extending upwardly from its lower end alongside the tower, wherein the clamp assembly includes a pipestring clamp that serves both the function of a transfer clamp for transferring the pipestring from a position alongside the tower but displaced from the pipe-laying path to a position approximately aligned with the pipe-laying path, and the function of a line-up clamp for lining up the pipestring with the end of the pipeline.
-
2.发明授权Enantiomerically pure (R)-albuterol dibenzoyltartrate and protected analogs thereof 失效对映异构纯的（R） - 苦参酒精酸二苯甲酰酒石酸盐及其保护的类似物公开(公告)号：US07482489B2
公开(公告)日：2009-01-27
申请号：US11133721
申请日：2005-05-20
IPC分类号： C07C215/30 , A61K31/137 , A61P11/06 , A61P11/08
CPC分类号： C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要： Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hydrochloride of the invention and at least one pharmaceutically-acceptable excipient are also provided.
摘要翻译： 提供了制备（R）-SLB.D-DBTA盐和盐酸莱布列特罗的方法。 还提供盐酸左美沙芬醇降解产物及其制备方法。 还提供了包含本发明的至少一种盐酸莱布列特和至少一种药学上可接受的赋形剂的药物组合物。
-
公开(公告)号：US07473804B2
公开(公告)日：2009-01-06
申请号：US11187349
申请日：2005-07-21
申请人： Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
发明人： Judith Aronhime , Stefano Bianchi , Eugenio Castelli , Paola Daverio , Silvia Mantovani , Adrienne Kovacsne-Mezei
IPC分类号： C07C213/08 , C07C217/62 , A61K31/135
CPC分类号： C07C217/48
摘要： The present invention provides novel crystalline polymorph forms of atomoxetine hydrochloride denominated Forms B and C and methods for their preparation, as well as methods for the preparation of Form A. The present invention provides pharmaceutical compositions that comprise atomoxetine hydrochloride Form B, Form C, or mixtures thereof that can be used to treat attention deficit/hyperactivity disorder.
摘要翻译： 本发明提供了以盐酸阿托西汀形式B和C的新型结晶多晶型形式及其制备方法，以及制备形式A的方法。本发明提供药物组合物，其包含盐酸阿托西汀形式B，C型或 可用于治疗注意力缺陷/多动障碍的混合物。
-
公开(公告)号：US20080021244A1
公开(公告)日：2008-01-24
申请号：US11827481
申请日：2007-07-11
申请人： Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
发明人： Valeriano Merli , Silvia Mantovani , Stefano Bianchi , Paola Daverio , Angelo Spreafico , Judith Aronhime , Adrienne Kovacsne-Mezei
IPC分类号： C07C213/00
CPC分类号： C07C229/38 , C07C215/60 , C07C217/48 , C07C227/34
摘要： The invention is directed to processes for making levalbuterol HCl Polymorph A from by suspending or forming a first slurry of (R)-SLB(D)-DBTA in at least a first organic solvent, adding HCl to the suspension or slurry of the solid (R)-SLB.D-DBTA until the (R)-SLB.D-DBTA forms levalbuterol HCl Polymorph A, and isolating the levalbuterol HCl Polymorph A.
-
5.发明申请Process for the preparation of 1-amino-3,5-dimethyladamantane hydrochloride 审中-公开1-氨基-3,5-二甲基金刚烷盐酸盐的制备方法公开(公告)号：US20060173215A1
公开(公告)日：2006-08-03
申请号：US11330681
申请日：2006-01-11
IPC分类号： C07C231/06
CPC分类号： C07C211/38 , C07C209/62 , C07C231/06 , C07C2603/74 , C07C233/06
摘要： A process for the preparation of memantine hydrochloride, intermediates thereof and its hydrochloric acid form are provided.
摘要翻译： 提供了制备美金刚盐酸盐，其中间体及其盐酸形式的方法。
-
公开(公告)号：US20060009530A1
公开(公告)日：2006-01-12
申请号：US11170379
申请日：2005-06-28
申请人： Eugenio Castelli , Giuseppe Monaco , Silvia Mantovani , Paola Daverio , Paolo Riva , Alessandra Vailati , Stefano Bianchi
发明人： Eugenio Castelli , Giuseppe Monaco , Silvia Mantovani , Paola Daverio , Paolo Riva , Alessandra Vailati , Stefano Bianchi
IPC分类号： A61K31/135
CPC分类号： C07C217/16 , C07B2200/07 , C07C213/06 , C07C213/08 , C07C217/48
摘要： The present invention provides a process for the optical resolution of racemic tomoxetine under reaction conditions that improve reaction yields and optical purity. The invention also provides an epimerization process for the (S)-(+) enantiomer. The invention further provides the conversion of the enantiomer obtained from the optical resolution into atomoxetine or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供了在提高反应产率和光学纯度的反应条件下旋光拆分外消旋的托莫西汀的方法。 本发明还提供了（S） - （+）对映体的差向异构化方法。 本发明还提供了从光学拆分得到的对映异构体转化成阿托莫西汀或其药学上可接受的盐。
-
公开(公告)号：US06800759B2
公开(公告)日：2004-10-05
申请号：US10392601
申请日：2003-03-19
申请人： Merli Valeriano , Paola Daverio , Stefano Bianchi
发明人： Merli Valeriano , Paola Daverio , Stefano Bianchi
IPC分类号： C07D4702
CPC分类号： C07D513/04 , A61K31/4743 , Y02P20/582
摘要： Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
摘要翻译： 提供氯吡格雷的对映异构体分离方法，将氯吡格雷的一种对映异构体转化为氯吡格雷的另一种对映异构体。 通过从烃或烃和共溶剂，优选DMF：甲苯的混合物中结晶（S）对映异构体作为樟脑磺酸盐分离对映异构体。 然后将（R）对映异构体外消旋化并通过与催化量的碱，优选与叔丁醇反应而再循环。
-
公开(公告)号：USRE37813E1
公开(公告)日：2002-08-06
申请号：US09547936
申请日：2000-04-11
IPC分类号： C07C4565
CPC分类号： C07C49/255 , C07C45/455 , C07C45/65 , C07C45/81 , C07C45/85
摘要： New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
摘要翻译： 用于合成称为萘丁美酮的抗炎药物的新方法，其包括使2-乙酰基-5-溴-6-甲氧基萘与乙酸烷基酯在碱性醇化物存在下反应，得到4-（5-溴-6-甲氧基 - 2-萘基）-4-羟基丁-3-烯-2-酮，通过极性溶剂中的催化氢化和碱的存在，得到4-（6-甲氧基-2-萘基）丁-2-酮，称为萘丁酮 。
-
公开(公告)号：US5750793A
公开(公告)日：1998-05-12
申请号：US788054
申请日：1997-01-23
CPC分类号： C07C49/255 , C07C45/455 , C07C45/65 , C07C45/81 , C07C45/85
摘要： New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
-
10.发明申请PIPELINE ABANDON AND RECOVER METHOD AND SYSTEM USING A ROPE CONNECTED TO THE PIPELINE, AND ADAPTER FOR IMPLEMENTING THE METHOD 审中-公开管道连接和回收方法和系统，使用连接到管道的绳索，以及适用于实施方法的适配器公开(公告)号：US20140294511A1
公开(公告)日：2014-10-02
申请号：US14111081
申请日：2012-04-16
申请人： Stefano Bianchi , Sergio Bogge , Massimo Pulici
发明人： Stefano Bianchi , Sergio Bogge , Massimo Pulici
IPC分类号： F16L1/23
CPC分类号： F16L1/23 , B65H51/105 , F16L1/207
摘要： A pipeline A/R method using a rope connected to the pipeline, the method including winding/unwinding the rope utilizing a hauling machine to exert pull on the rope; adapting a crawler pipeline tensioning device to grip the rope in the crawler tensioning device; and exerting additional pull on a portion of rope between the crawler tensioning device and the pipeline.
摘要翻译： 一种使用连接在管道上的绳索的管道A / R方法，该方法包括使用牵引机对绳索进行卷绕/退卷以对绳索进行牵引; 适应履带式管道张紧装置以抓住履带张紧装置中的绳索; 并且在履带张紧装置和管道之间的绳索的一部分上施加额外的拉力。
-
-
-
-
-
-
-
-
-
搜索结果
55 条记录 (耗时 0.017 秒)
