发明授权
- 专利标题： Compositions and methods for the identification, assessment, prevention and therapy of human cancers
- 专利标题（中）： 用于鉴定，评估，预防和治疗人类癌症的组合物和方法
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申请号： US10071510申请日： 2002-02-08
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公开(公告)号： US07338758B2公开(公告)日： 2008-03-04
- 发明人: Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
- 申请人： Edwin Clark , Tallessyn Grenfell-Lee , Karen Lu , Lynn Hartmann , Jeffrey L. Brown
- 申请人地址： US MN Rochester US TX Austin US MA Cambridge
- 专利权人： Mayo Foundation for Medical Education And Research.,Board of Regents, The University of Texas System.,Millennium Pharmaceuticals, Inc.
- 当前专利权人： Mayo Foundation for Medical Education And Research.,Board of Regents, The University of Texas System.,Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US MN Rochester US TX Austin US MA Cambridge
- 代理机构： Lahive & Cockfield, LLP Maria Laccotripe Zacharakis
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.
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