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    Compositions and methods for the identification, assessment, prevention and therapy of human cancers
    1.
    发明授权
    Compositions and methods for the identification, assessment, prevention and therapy of human cancers 失效
    用于鉴定，评估，预防和治疗人类癌症的组合物和方法

    公开(公告)号：US08080368B2

    公开(公告)日：2011-12-20

    申请号：US12956500

    申请日：2010-11-30

    申请人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown ,  Robert C. Bast, Jr. ,  Gordon B. Mills

    发明人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown ,  Robert C. Bast, Jr. ,  Gordon B. Mills

    IPC分类号： C12Q1/68 ,  G01N33/53

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2500/00 ,  G01N2800/52

    摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.

    摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明特征在于许多“灵敏度标记物”。这些标记物在大多数或所有细胞系中表达，对于用药剂治疗敏感并且在细胞中不表达（或以相当低的水平表达） 耐药性。 本发明还具有许多“抗性标记”。这些标记物在大多数或所有细胞系中表达，其对于用药剂治疗有抗性并且在细胞中不表达（或以相当低的水平表达） 对该药物的治疗敏感。 本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

    NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS
    4.
    发明申请
    NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS 审中-公开
    人类癌症鉴定，评估，预防和治疗的新组合物和方法

    公开(公告)号：US20120141604A1

    公开(公告)日：2012-06-07

    申请号：US13289230

    申请日：2011-11-04

    申请人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown ,  Robert C. Bast, JR. ,  Gordon B. Mills

    发明人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown ,  Robert C. Bast, JR. ,  Gordon B. Mills

    IPC分类号： C40B30/04 ,  A61K33/24 ,  A61P35/00 ,  A61K31/337

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2500/00 ,  G01N2800/52

    摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.

    摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明特征在于许多“灵敏度标记物”。这些标记物在大多数或所有细胞系中表达，对于用药物治疗敏感并且在细胞中未表达（或以相当低的水平表达） 耐药性。 本发明还具有许多“抗性标记”。这些标记物在大多数或所有细胞系中表达，其对于用药剂治疗有抗性并且在细胞中不表达（或以相当低的水平表达） 对该药物的治疗敏感。 本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

    NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS
    5.
    发明申请
    NOVEL COMPOSITIONS AND METHODS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF HUMAN CANCERS 失效
    人类癌症鉴定，评估，预防和治疗的新组合物和方法

    公开(公告)号：US20110104306A1

    公开(公告)日：2011-05-05

    申请号：US12956500

    申请日：2010-11-30

    申请人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown

    发明人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown

    IPC分类号： A61K33/24 ,  C12Q1/02 ,  C12Q1/68 ,  A61P35/00 ,  A61K31/337

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2500/00 ,  G01N2800/52

    摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.

    摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明特征在于许多“灵敏度标记物”。这些标记物在大多数或所有细胞系中表达，对于用药物治疗敏感并且在细胞中未表达（或以相当低的水平表达） 耐药性。 本发明还具有许多“抗性标记”。这些标记物在大多数或所有细胞系中表达，其对于用药剂治疗有抗性并且在细胞中不表达（或以相当低的水平表达） 对该药物的治疗敏感。 本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

    Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers
    6.
    发明申请
    Novel compositions and methods for the identification, assessment, prevention and therapy of human cancers 失效
    用于鉴定，评估，预防和治疗人类癌症的新型组合物和方法

    公开(公告)号：US20080286780A1

    公开(公告)日：2008-11-20

    申请号：US12002783

    申请日：2007-12-17

    申请人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown

    发明人： Edwin Clark ,  Tallessyn Grenfell-Lee ,  Karen Lu ,  Lynn Hartmann ,  Jeffrey L. Brown

    IPC分类号： C12Q1/68 ,  C12Q1/02 ,  G01N33/574

    CPC分类号： G01N33/6893 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/57496 ,  G01N2500/00 ,  G01N2800/52

    摘要： The present invention is directed to the identification of markers that can be used to determine whether tumors are sensitive or resistant to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. The invention features a number of “sensitivity markers.” These are markers that are expressed in most or all cell lines that are sensitive to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are resistant to treatment with that agent. The invention also features a number of “resistance markers.” These are markers that are expressed in most or all cell lines that are resistant to treatment with an agent and which are not expressed (or are expressed at a rather low level) in cells that are sensitive to treatment with that agent. The invention also features marker sets that can predict patients that are likely to respond or not to respond to an agent.

    摘要翻译： 本发明涉及可用于确定肿瘤是否对治疗剂敏感或抗性的标志物的鉴定。 本发明还涉及治疗靶标的鉴定。 本发明具有许多“灵敏度标记”。 这些标记物在大多数或所有细胞系中表达，其对于用药物治疗敏感并且在对该药物治疗有抗性的细胞中不表达（或以相当低的水平表达）表达。 本发明还具有许多“电阻标记”。 这些是在大多数或所有细胞系中表达的标记，其对于用药物治疗是有抗性的，并且在对用该药物治疗敏感的细胞中不表达（或以相当低的水平表达）表达。 本发明还具有可以预测可能响应或不响应于药剂的患者的标记物组。

    Drilling mud degasser
    8.
    发明授权
    Drilling mud degasser 失效
    钻井泥浆机

    公开(公告)号：US3676984A

    公开(公告)日：1972-07-18

    申请号：US3676984D

    申请日：1970-10-22

    申请人： JOSEPH EDWIN CLARK

    发明人： CLARK JOSEPH EDWIN

    IPC分类号： B01D19/00 ,  E21B21/06

    CPC分类号： E21B21/067 ,  B01D19/0021

    摘要： A novel inlet and baffle structure for a drilling and degasser is provided. Gas-cut mud is fed into the degasser vacuum chamber through a horizontal inlet pipe having a long slot cut in its bottom wall. The mud flow is formed into a thin curtain as it passes through this slot. At the same time, its rate of movement is accelerated, with a consequent increase in shear and drop in viscosity. The mud immediately contacts a generally horizontal baffle. The flow is divided into two turbulent, thin layers. It is then conducted through a system of baffles. Due to the change in mud viscosity, induced turbulence and the forming of the mud flow into thin layers of large area, the vacuum within the chamber is able to effectively separate the entrained gas from the mud.

    摘要翻译： 提供了一种用于钻孔和脱气机的新型入口和挡板结构。 气体切割泥浆通过其底壁中具有长槽切割的水平入口管进入脱气器真空室。 泥浆流通过这个槽时形成一个薄的窗帘。 同时，其运动速度加快，随之而来的剪切和粘度下降。 泥浆立即接触一个大致水平的挡板。 流动分为两层湍流薄层。 然后通过挡板系统进行。 由于泥浆粘度的变化，引起的湍流和泥浆流形成大面积的薄层，室内的真空能够有效地将夹带的气体与泥浆分离。