发明授权
US07338965B2 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
失效
3,4-二取代，3,5-二取代和3,4,5-取代的哌啶
- 专利标题： 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
- 专利标题（中）： 3,4-二取代，3,5-二取代和3,4,5-取代的哌啶
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申请号： US10299746申请日： 2002-11-19
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公开(公告)号： US07338965B2公开(公告)日： 2008-03-04
- 发明人: Joseph B. Moon , Shon R. Pulley , Daniel H. Rich , David L. Brown , Barbara Jagodzinska , Varghese John , John Jacobs
- 申请人： Joseph B. Moon , Shon R. Pulley , Daniel H. Rich , David L. Brown , Barbara Jagodzinska , Varghese John , John Jacobs
- 申请人地址： US MI Kalamazoo US CA South San Francisco
- 专利权人： Pharmacia & Upjohn Company,Elan Pharmaceuticals, Inc.
- 当前专利权人： Pharmacia & Upjohn Company,Elan Pharmaceuticals, Inc.
- 当前专利权人地址： US MI Kalamazoo US CA South San Francisco
- 代理机构： McDonnell Boehnen Hulbert & Berghoff LLP
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; C07D211/42
摘要：
The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers. One embodiment of the invention relates to compounds having the structure: where Z is CR or N, and R1, R2 and R3 are as described in the specification.
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