发明授权
- 专利标题： Peptidomimetic inhibitors of STAT activity and uses thereof
- 专利标题（中）： STAT活性的拟肽抑制剂及其用途
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申请号： US10784309申请日： 2004-02-20
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公开(公告)号： US07342095B2公开(公告)日： 2008-03-11
- 发明人: James Turkson , Richard Jove , Said M. Sebti , Andrew D. Hamilton
- 申请人： James Turkson , Richard Jove , Said M. Sebti , Andrew D. Hamilton
- 申请人地址： US FL Tampa
- 专利权人： University of South Florida
- 当前专利权人： University of South Florida
- 当前专利权人地址： US FL Tampa
- 代理机构： Saliwanchik, Lloyd & Saliwanchik
- 主分类号： A61K38/06
- IPC分类号： A61K38/06 ; A61K38/00 ; A61K38/16
摘要：
The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include compounds of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.
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