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    MATERIALS AND METHODS FOR TREATMENT OF CANCER AND IDENTIFICATION OF ANTI-CANCER COMPOUNDS
    1.
    发明申请
    MATERIALS AND METHODS FOR TREATMENT OF CANCER AND IDENTIFICATION OF ANTI-CANCER COMPOUNDS 审中-公开
    治疗癌症和抗癌化合物鉴定的材料与方法

    公开(公告)号：US20140296128A1

    公开(公告)日：2014-10-02

    申请号：US14246798

    申请日：2014-04-07

    申请人： SAID M. SEBTI ,  RICHARD JOVE

    发明人： SAID M. SEBTI ,  RICHARD JOVE

    IPC分类号： A61K31/575 ,  G01N33/574 ,  A61K45/06

    CPC分类号： A61K31/575 ,  A61K31/56 ,  A61K31/58 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6872 ,  G01N2333/4706 ,  G01N2500/00

    摘要： The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the invention concerns methods of inhibiting the growth of a tumor by administering a cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK and/or STAT3 inhibition and anti-tumor activity.

    摘要翻译： 本发明涉及肿瘤和癌组织的治疗以及通过调节JAK / STAT3细胞内信号传导来预防肿瘤发生和恶性转化。 本发明涉及含有葫芦素I或其药学上可接受的盐或类似物的药物组合物。 本发明的另一方面涉及通过向患者施用葫芦素I或其药学上可接受的盐或类似物来抑制肿瘤生长的方法，其中所述肿瘤的特征在于JAK / STAT3细胞内信号传导途径的组成型激活 。 本发明还涉及使用葫芦素I或其药学上可接受的盐或类似物在体外或体内缓和JAK和/或STAT3信号传导途径的方法。 本发明的另一方面涉及用于筛选候选化合物用于JAK和/或STAT3抑制和抗肿瘤活性的方法。

    Materials and methods for treatment of cancer and identification of anti-cancer compounds
    3.
    发明授权
    Materials and methods for treatment of cancer and identification of anti-cancer compounds 有权
    用于治疗癌症的材料和方法以及抗癌化合物的鉴定

    公开(公告)号：US07998947B2

    公开(公告)日：2011-08-16

    申请号：US10472056

    申请日：2002-03-28

    申请人： Said M. Sebti ,  Richard Jove

    发明人： Said M. Sebti ,  Richard Jove

    IPC分类号： A61K31/56

    CPC分类号： A61K31/575 ,  A61K31/56 ,  A61K31/58 ,  A61K45/06 ,  G01N33/5011 ,  G01N33/574 ,  G01N33/6872 ,  G01N2333/4706 ,  G01N2500/00

    摘要： The subject invention pertains to the treatment of tumors and cancerous tissues and the prevention of tumorigenesis and malignant transformation through the modulation of JAK/STAT3 intracellular signaling. The subject invention concerns pharmaceutical compositions containing cucurbitacin I, or a pharmaceutically acceptable salt or analog thereof, to a patient, wherein the tumor is characterized by the constitutive activation of the JAK/STAT3 intracellular signaling pathway. The present invention further pertains to methods of moderating the JAK and/or STAT3 signaling pathways in vitro or in vivo using cucurbitacin I, or a pharmaceutically acceptable salt or analog therof. Another aspect of the present invention concerns a method for screening candidate compounds for JAK AND/or STAT3 inhibition and anti-tumor activity.

    摘要翻译： 本发明涉及肿瘤和癌组织的治疗以及通过调节JAK / STAT3细胞内信号传导来预防肿瘤发生和恶性转化。 本发明涉及含有葫芦素I或其药学上可接受的盐或类似物的药物组合物。 本发明的另一方面涉及通过向患者施用葫芦素I或其药学上可接受的盐或类似物来抑制肿瘤生长的方法，其中所述肿瘤的特征在于JAK / STAT3细胞内信号传导途径的组成型激活 。 本发明还涉及使用葫芦素I或其药学上可接受的盐或类似物来体外或体内缓和JAK和/或STAT3信号通路的方法。 本发明的另一方面涉及用于筛选候选化合物用于JAK和/或STAT3抑制和抗肿瘤活性的方法。

    Peptidomimetic inhibitors of STAT activity and uses thereof
    7.
    发明授权
    Peptidomimetic inhibitors of STAT activity and uses thereof 有权
    STAT活性的拟肽抑制剂及其用途

    公开(公告)号：US07342095B2

    公开(公告)日：2008-03-11

    申请号：US10784309

    申请日：2004-02-20

    申请人： James Turkson ,  Richard Jove ,  Said M. Sebti ,  Andrew D. Hamilton

    发明人： James Turkson ,  Richard Jove ,  Said M. Sebti ,  Andrew D. Hamilton

    IPC分类号： A61K38/06 ,  A61K38/00 ,  A61K38/16

    CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K5/06191 ,  C07K5/0827

    摘要： The subject invention concerns compositions and methods for blocking cancer cell growth or proliferation and/or inducing cancer cell death. Compositions of the present invention are peptidomimetics that inhibit STAT function. Peptidomimetics of the invention include compounds of the formula RY*L (where Y* represents phosphotyrosine), with the R group at the Y-1 position. Peptidomimetics of the invention disrupt Stat3 activation and function. Peptidomimetics of the invention significantly inhibit tumor cell growth and induce tumor cell death.

    摘要翻译： 本发明涉及用于阻断癌细胞生长或增殖和/或诱导癌细胞死亡的组合物和方法。 本发明的组合物是抑制STAT功能的肽模拟物。 本发明的肽模拟物包括式RY * L（其中Y *表示磷酸酪氨酸）的化合物，其中R基团在Y-1位。 本发明的肽模拟物破坏Stat3的活化和功能。 本发明的肽模拟物显着抑制肿瘤细胞生长并诱导肿瘤细胞死亡。

    STAT3 ANTAGONISTS AND THEIR USES AS VACCINES AGAINST CANCER
    9.
    发明申请
    STAT3 ANTAGONISTS AND THEIR USES AS VACCINES AGAINST CANCER 审中-公开
    STAT3拮抗剂及其作为疫苗的疫苗使用

    公开(公告)号：US20100297061A1

    公开(公告)日：2010-11-25

    申请号：US12611732

    申请日：2009-11-03

    申请人： Hua Yu ,  Drew Pardoll ,  Richard Jove

    发明人： Hua Yu ,  Drew Pardoll ,  Richard Jove

    IPC分类号： A61K38/19 ,  A61P35/00 ,  A61K39/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P33/02 ,  A61P33/10

    CPC分类号： C07K16/18 ,  A61K39/0011 ,  A61K48/00 ,  A61K2039/5152 ,  A61K2039/5154 ,  A61K2039/55522 ,  C12N5/0693 ,  C12N2501/60

    摘要： The present invention relates to methods for treating and/or preventing cancer. In particular the present invention relates to ex vivo immunotherapeutic methods. The methods comprise decreasing Stat3 (signal transducer and activator of transcirption3) expression and/or function in tumor cells and the administration of such cells to a subject in need of treatment and/or prevention. Other methods of the invention comprise activation T-cells by co-culturing the T-cells with the tumor cells with decreased Stat3 expression or function. The invention further encompasses methods comprising decreasing Stat3 expression or function in antigen-presenting cells and co-administering tumor cells and the antigen-presenting cells with decreased Stat3 function to a patient. The invention further relates to methods for stimulating dendritic cell differentiation.

    摘要翻译： 本发明涉及治疗和/或预防癌症的方法。 特别地，本发明涉及离体免疫治疗方法。 所述方法包括降低肿瘤细胞中Stat3（信号转导和转录激活因子3）的表达和/或功能，并将此类细胞施用于需要治疗和/或预防的受试者。 本发明的其它方法包括通过与具有降低的Stat3表达或功能的肿瘤细胞共培养T细胞来活化T细胞。 本发明还包括降低Stat3在抗原呈递细胞中的表达或功能的降低，并且向患者共同施用具有降低的Stat3功能的肿瘤细胞和抗原呈递细胞。 本发明还涉及刺激树突状细胞分化的方法。