A refrigerant system has a controller associated with it that determines an equilibrium pressure when the system is inactive. The controller determines if the equilibrium pressure differs from an expected equilibrium pressure corresponding to a current ambient temperature and the selected refrigerant type. When the difference exceeds a selected threshold, the controller determines that the amount of refrigerant within the circuit is below a desired level. In one example, the controller provides an indication of a low charge amount. The disclosed technique allows early detection of refrigerant charge loss and differentiation between loss-of-charge and other failure modes. Consequently, system performance is enhanced, component damage is prevented, service interruptions and maintenance are reduced, exhaustive troubleshooting is avoided and potential exposure to refrigerant substances is minimized.