发明授权
US07354932B2 Chemokine receptor binding heterocyclic compounds with enhanced efficacy
有权
趋化因子受体结合杂环化合物具有增强的疗效
- 专利标题： Chemokine receptor binding heterocyclic compounds with enhanced efficacy
- 专利标题（中）： 趋化因子受体结合杂环化合物具有增强的疗效
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申请号： US10457034申请日： 2003-06-06
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公开(公告)号： US07354932B2公开(公告)日： 2008-04-08
- 发明人: Gary Bridger , Al Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri
- 申请人： Gary Bridger , Al Kaller , Curtis Harwig , Renato Skerlj , David Bogucki , Trevor R. Wilson , Jason Crawford , Ernest J. McEachern , Bem Atsma , Siqiao Nan , Yuanxi Zhou , Dominique Schols , Christopher Dennis Smith , Maria Rosaria Di Fluri
- 申请人地址： CA Langley, British Columbia
- 专利权人： Anormed, Inc.
- 当前专利权人： Anormed, Inc.
- 当前专利权人地址： CA Langley, British Columbia
- 代理机构： Morrison & Foerster LLP
- 主分类号： A61K31/4709
- IPC分类号： A61K31/4709 ; C07D403/12
摘要：
The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
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