公开(公告)号：US12129477B2

公开(公告)日：2024-10-29

申请号：US17578425

申请日：2022-01-18

申请人： Juno Therapeutics GmbH

发明人： Keenan Bashour ,  Semih U. Tareen

IPC分类号： C12N15/86 ,  C07K14/315 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

CPC分类号： C12N15/86 ,  C07K14/315 ,  C07K14/7051 ,  C07K16/2809 ,  C07K16/2818 ,  C12N5/0636 ,  C07K2317/55 ,  C07K2319/00 ,  C12N2500/32 ,  C12N2501/515 ,  C12N2740/10043

摘要： Provided herein are methods for transducing a plurality of cells in a composition of cells, such as a population of lymphocytes, containing viral particles. In some aspects, provided methods and reagents for the transduction of cell populations involve binding of agents to a molecule on the surface of the cells. In some cases, the reagents are multimerization reagents and the one or more agents are multimerized by reversibly binding to the reagent. In some aspects, the multimerized agent can provide for transduction and/or expansion or proliferation or other stimulation of a population of cells, and then such agents can be removed by disruption of the reversible bond. Also provided are compositions, apparatus and methods of use thereof.

公开(公告)号：US12126135B2

公开(公告)日：2024-10-22

申请号：US17078852

申请日：2020-10-23

申请人： Coherent Kaiserslautern GmbH

发明人： Christoph O. Schäfer ,  Louis McDonagh ,  Ralf Knappe

IPC分类号： H01S3/23 ,  H01S3/06 ,  H01S3/08 ,  H01S3/081

CPC分类号： H01S3/235 ,  H01S3/0606 ,  H01S3/08054 ,  H01S3/08059 ,  H01S3/08095 ,  H01S3/081

摘要： A multipass laser amplifier includes a mirror, a mirror device, a gain crystal, and refractive or diffractive beam-steering element. The gain crystal is positioned on a longitudinal axis of the multipass laser amplifier between the mirror and the mirror device. The beam-steering element is positioned on the longitudinal axis between the gain crystal and the mirror device. The beam-steering element has no optical power and deflects a laser beam, by refraction or diffraction, for each of multiple passes of the laser beam between the first mirror and the mirror device, such that each pass goes through the gain crystal for amplification of the laser beam and goes through a different respective off-axis portion of the beam-steering element. The no optical power of the beam-steering element enables maintaining a large beam size in the gain crystal, thereby facilitating amplification to high average power.

公开(公告)号：US12125087B2

公开(公告)日：2024-10-22

申请号：US17874273

申请日：2022-07-26

申请人： MDSAVE SHARED SERVICES INC.

发明人： Paul J. Ketchel, III ,  Ani Osborne

IPC分类号： G06Q30/00 ,  G06Q10/10 ,  G06Q20/06 ,  G06Q20/10 ,  G06Q20/38 ,  G06Q30/0201 ,  G06Q30/0207 ,  G06Q30/0601 ,  G16H10/60 ,  G16H40/20 ,  G16H70/20 ,  G16H20/00

CPC分类号： G06Q30/0621 ,  G06Q10/10 ,  G06Q20/065 ,  G06Q20/10 ,  G06Q20/381 ,  G06Q30/0206 ,  G06Q30/0239 ,  G06Q30/0613 ,  G06Q30/0629 ,  G06Q30/0633 ,  G16H10/60 ,  G16H40/20 ,  G16H70/20 ,  G16H20/00

摘要： An exemplary healthcare services recommender implementation may be configured to recommend selectively redeemable bundled services comprising care for conditions predicted as likely by a machine learning model based on patient data input. The likely conditions may be predicted for a patient or a patient population comprising a plurality of patients. The machine learning model may comprise a neural network trained to determine a probability distribution of patient condition trends for a future time period based on patient data input. The patient data input may comprise data from an Electronic Medical Record (EMR), diagnosis, lab test, patient-provided information such as survey/symptom data, and/or wearable device data. The machine learning model may be trained using a training data set including at least healthcare outcomes sampled during a past time period from a plurality of patient healthcare episodes each comprising a plurality of procedures performed for the patient in at least one encounter.

公开(公告)号：US12123880B2

公开(公告)日：2024-10-22

申请号：US18321542

申请日：2023-05-22

申请人： Genzyme Corporation

发明人： Xiaoying Jin ,  Catherine O'Riordan ,  Lin Liu ,  Kate Zhang

IPC分类号： G01N33/68 ,  C12N15/86 ,  G01N30/72 ,  G01N30/02

CPC分类号： G01N33/6848 ,  C12N15/86 ,  G01N30/72 ,  C12N2750/14123 ,  C12N2750/14143 ,  G01N2030/027

摘要： Provided herein are methods for determining the serotype of a virus particle and/or or determining the heterogeneity of a virus particle (e.g., an AAV particle). In other embodiments, the invention provides methods to determine the heterogeneity of AAV particles. In some aspects, the invention provides viral particles (e.g., rAAV particles) with improved stability and/or improved transduction efficiency by increasing the acetylation and/or deamidation of capsid proteins.

公开(公告)号：US12116638B2

公开(公告)日：2024-10-15

申请号：US17673718

申请日：2022-02-16

申请人： Foundation Medicine, Inc.

发明人： Maureen T. Cronin ,  Garrett Michael Frampton ,  Doron Lipson ,  Vincent A. Miller ,  Gary Palmer ,  Jeffrey S. Ross ,  Philip James Stephens ,  Roman Yelensky

IPC分类号： C12Q1/6886 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/536 ,  A61K31/5415 ,  A61K31/565 ,  A61K31/567 ,  A61K31/675 ,  A61K45/06 ,  C07K14/72 ,  C07K16/28

CPC分类号： C12Q1/6886 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/536 ,  A61K31/5415 ,  A61K31/565 ,  A61K31/567 ,  A61K31/675 ,  A61K45/06 ,  C07K14/72 ,  C07K16/2869 ,  C07K2317/34 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Novel mutant ESR1 molecules and uses are disclosed.

公开(公告)号：US12116626B2

公开(公告)日：2024-10-15

申请号：US18450212

申请日：2023-08-15

申请人： 10x Genomics, Inc.

发明人： Shankar Shastry

IPC分类号： C12Q1/68 ,  C12N9/12 ,  C12Q1/686

CPC分类号： C12Q1/686 ,  C12N9/1247

摘要： The present disclosure relates in some aspects to recombinant Bacillus phage AP50 polymerases, modified AP50 polymerases, and compositions thereof. Also provided are methods of using the recombinant and/or modified AP50 polymerases for nucleic acid amplification (e.g., rolling circle amplification). In some aspects, the compositions and methods disclosed herein provide more robust amplification (e.g., RCA) reactions for improved in vitro and in situ analysis.

公开(公告)号：US12115614B2

公开(公告)日：2024-10-15

申请号：US16651735

申请日：2018-09-28

申请人： MAKINO MILLING MACHINE CO., LTD.

发明人： Tadashi Kasahara ,  Kazunari Ishii

IPC分类号： B23Q17/24 ,  B23Q15/14 ,  B23Q15/22 ,  B23Q17/22 ,  G05B19/29 ,  G06T7/00 ,  G06T7/73

CPC分类号： B23Q17/249 ,  B23Q15/14 ,  B23Q15/22 ,  B23Q17/22 ,  B23Q17/24 ,  B23Q17/2414 ,  B23Q17/2428 ,  G05B19/291 ,  G06T7/0004 ,  G06T7/75 ,  G06T2207/30164

摘要： When measuring the position of a workpiece fixed to a table of a machine tool: rotary feed axes of the machine tool are pivoted such that an upper surface of the table faces in the direction of a line of sight of a camera, and an image of the workpiece is captured; the rotary feed axes are pivoted such that a side surface of the table faces in the direction of the line of sight of an image capturing device, and an image of the workpiece is captured; and the position of the workpiece is measured on the machine tool on the basis of the captured images.

公开(公告)号：US12114923B2

公开(公告)日：2024-10-15

申请号：US18201167

申请日：2023-05-23

申请人： Shockwave Medical, Inc.

发明人： John M. Adams ,  Thomas G. Goff ,  Doug Hakala

IPC分类号： A61B18/14 ,  A61B17/22 ,  A61B17/225 ,  A61B17/3207 ,  A61B18/00

CPC分类号： A61B18/1492 ,  A61B17/22022 ,  A61B18/00 ,  A61B17/2202 ,  A61B2017/22024 ,  A61B2017/22025 ,  A61B17/22029 ,  A61B2017/22051 ,  A61B2017/22058 ,  A61B2017/22061 ,  A61B2017/22062 ,  A61B2017/22098 ,  A61B17/2251 ,  A61B17/320725

摘要： An apparatus includes a balloon adapted to be placed adjacent a calcified region of a body. The balloon is inflatable with a liquid. The apparatus further includes a shock wave generator within the balloon that produces shock waves that propagate through the liquid for impinging upon the calcified region adjacent the balloon. The shock wave generator includes a plurality of shock wave sources distributed within the balloon.

公开(公告)号：US12110548B2

公开(公告)日：2024-10-08

申请号：US17165802

申请日：2021-02-02

申请人： 10x Genomics, Inc.

发明人： Felice Alessio Bava

IPC分类号： C12Q1/6874 ,  C12Q1/6876

CPC分类号： C12Q1/6874 ,  C12Q1/6876

摘要： In some aspects, provided herein are methods for analyzing a nucleic acid comprising first and second regions of interest flanking an adaptor region, comprising hybridizing an anchor to the adaptor region, analyzing the first region of interest from one end of the anchor using probe ligation (e.g., sequencing-by-ligation), and binding a polymerase to the other end of the anchor and optionally incorporating a nucleotide and/or analog thereof into the anchor by the polymerase using the second region of interest or a probe bound thereto as a template. In some embodiments, the second region of interest is used as a template for sequencing-by-synthesis. In some embodiments, spatially resolved detections of analytes are performed at a cellular or sub-cellular resolution which involve correlating signals associated with analytes with specific spatial locations in a biological sample.

公开(公告)号：US12104350B2

公开(公告)日：2024-10-01

申请号：US17594519

申请日：2020-11-26

申请人： Beijing Baidu Netcom Science and Technology Co., LTD.

发明人： Lingfeng Qian ,  Pinxin Long ,  Liangjun Zhang

IPC分类号： E02F3/43 ,  G05D1/00 ,  G05D1/02

CPC分类号： E02F3/435 ,  G05D1/0223

摘要： A speed determination method, an electronic device and a computer storage medium are provided, relates to the field of computer technology, and may be applied to the field of artificial intelligence, especially the field of automated driving. The method includes: determining an expected speed direction of a controlled point of a first controlled target according to an actual location of the controlled point of the first controlled target and a preset trajectory of the controlled point of the first controlled target, wherein the first controlled target is one of a plurality of controlled targets having a kinematic relationship; and determining a target speed of at least one controlled target of the plurality of controlled targets according to the expected speed direction of the controlled point of the first controlled target and the kinematic relationship.