发明授权
- 专利标题： Biarylurea derivatives
- 专利标题（中）： 双芳脲衍生物
-
申请号： US11002422申请日： 2004-12-03
-
公开(公告)号： US07354946B2公开(公告)日： 2008-04-08
- 发明人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
- 申请人： Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
- 申请人地址： JP Tokyo
- 专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理机构： Wenderoth, Lind & Ponack, L.L.P.
- 优先权： JP1999/211384 19990726
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D405/12 ; A61K31/423 ; A61K31/424
摘要：
The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof:Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
公开/授权文献
- US20070027147A1 Biarylurea derivatives 公开/授权日：2007-02-01
信息查询
