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公开(公告)号:US20070027147A1
公开(公告)日:2007-02-01
申请号:US11002422
申请日:2004-12-03
申请人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
发明人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
IPC分类号: A61K31/538 , A61K31/4545 , A61K31/4439 , C07D413/14 , C07D403/14
CPC分类号: C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/40 , C07D239/42 , C07D241/20 , C07D277/48 , C07D277/54 , C07D277/56 , C07D277/82 , C07D401/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
摘要翻译: 本发明涉及式(I)化合物及其制备方法及其用途:式(I)其中:Ar为含氮杂芳环; X和Z各自为碳原子,等等; Y是CO,等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子,等等; “img id =”custom-character-00001“he =”3.13mm“wi =”6.01mm“file =”US20070027147A1-20070201-P00001.TIF“alt =”custom character“img-content =”character“ img-format =“tif”/>是单键或双键。 根据本发明,本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂,因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。
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公开(公告)号:US07354946B2
公开(公告)日:2008-04-08
申请号:US11002422
申请日:2004-12-03
申请人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
发明人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
IPC分类号: C07D498/04 , C07D405/12 , A61K31/423 , A61K31/424
CPC分类号: C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/40 , C07D239/42 , C07D241/20 , C07D277/48 , C07D277/54 , C07D277/56 , C07D277/82 , C07D401/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof:Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
摘要翻译: 本发明涉及式(I)化合物及其制备方法及其用途:式(I)其中:Ar为含氮杂芳环; X和Z各自为碳原子,等等; Y是CO,等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子,等等; “img id =”CUSTOM-CHARACTER-00001“he =”3.13mm“wi =”6.01mm“file =”US07354946-20080408-P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/>是单键或双键。 根据本发明,本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂,因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。
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公开(公告)号:US09156827B2
公开(公告)日:2015-10-13
申请号:US13643002
申请日:2011-04-28
申请人: Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Nae Saito , Hirofumi Nakano , Masanao Abe , Akiko Tanaka , Teruki Honma , Shigeyuki Yokoyama , Keiko Tsuganezawa , Hitomi Yuki
发明人: Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Nae Saito , Hirofumi Nakano , Masanao Abe , Akiko Tanaka , Teruki Honma , Shigeyuki Yokoyama , Keiko Tsuganezawa , Hitomi Yuki
IPC分类号: C07D405/14 , A61K31/36 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D405/06 , C07D493/04 , C07D413/14 , C07D417/14 , C07D471/04
CPC分类号: C07D405/14 , A61K31/36 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D405/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
摘要: An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6 alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; R4 represents hydrogen atom, a C1-6 alkyl group, a C1-6 alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6 alkyl group and the like; R8 represents hydrogen atom, a C1-6 alkyl group and the like; A represents —O—, —S—, or —CH2—; D represents —C═ or —N═; X represents methylene group, —O—, or —CO—; Q represents —N═ or —C(R8)═; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.
摘要翻译: 包含由式(I)表示的化合物[R 1表示氢原子,羟基,C 1-6烷氧基等]的抗癌剂, R2和R3表示氢原子,卤素原子,C1-6烷基等; R4表示氢原子,C1-6烷基,C1-6烷基磺酰基等; R5代表氢原子或取代基; 代表单键或双键; R6和R7表示氢原子,C1-6烷基等; R8表示氢原子,C1-6烷基等; A表示-O - , - S-或-CH 2 - ; D表示-C≡或-N =; X表示亚甲基,-O-或-CO-; Q表示-N =或-C(R 8)= Y表示杂环基或氨基],这表现出对pim-1激酶的优异抑制活性。
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公开(公告)号:US20130102776A1
公开(公告)日:2013-04-25
申请号:US13643002
申请日:2011-04-28
申请人: Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Nae Saito , Hirofumi Nakano , Masanao Abe , Akiko Tanaka , Teruki Honma , Shigeyuki Yokoyama , Keiko Tsuganezawa , Hitomi Yuki
发明人: Tetsuo Nagano , Takayoshi Okabe , Hirotatsu Kojima , Nae Saito , Hirofumi Nakano , Masanao Abe , Akiko Tanaka , Teruki Honma , Shigeyuki Yokoyama , Keiko Tsuganezawa , Hitomi Yuki
IPC分类号: C07D405/14 , C07D493/04 , C07D413/14 , C07D471/04 , C07D417/14 , C07D405/06
CPC分类号: C07D405/14 , A61K31/36 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D405/06 , C07D413/14 , C07D417/14 , C07D471/04 , C07D493/04
摘要: An anticancer agent comprising a compound represented by the formula (I) [R1 represents hydrogen atom, hydroxyl group, a C1-6 alkoxy group and the like; R2 and R3 represents hydrogen atom, a halogen atom, a C1-6 alkyl group and the like; R4 represents hydrogen atom, a C1-6 alkyl group, a C1-6 alkylsulfonyl group and the like; R5 represents hydrogen atom or a substituent; represents a single bond or a double bond; R6 and R7 represents hydrogen atom, a C1-6 alkyl group and the like; R8 represents hydrogen atom, a C1-6 alkyl group and the like; A represents —O—, —S—, or —CH2—; D represents —C═ or —N═; X represents methylene group, —O—, or —CO—; Q represents —N═ or —C(R8)═; and Y represents a heterocyclic group or amino group], which shows a superior inhibitory activity against pim-1 kinase.
摘要翻译: 包含由式(I)表示的化合物[R 1表示氢原子,羟基,C 1-6烷氧基等]的抗癌剂, R2和R3表示氢原子,卤素原子,C1-6烷基等; R4表示氢原子,C1-6烷基,C1-6烷基磺酰基等; R5代表氢原子或取代基; 代表单键或双键; R6和R7表示氢原子,C1-6烷基等; R8表示氢原子,C1-6烷基等; A表示-O - , - S-或-CH 2 - ; D表示-C =或-N =; X表示亚甲基,-O-或-CO-; Q表示-N =或-C(R8)=; Y表示杂环基或氨基],这表现出对pim-1激酶的优异抑制活性。
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公开(公告)号:US06958333B1
公开(公告)日:2005-10-25
申请号:US10031795
申请日:2000-07-26
申请人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
发明人: Takashi Hayama , Kyoko Hayashi , Teruki Honma , Ikuko Takahashi
IPC分类号: A61P35/00 , A61P43/00 , C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/40 , C07D239/42 , C07D241/20 , C07D277/48 , C07D277/54 , C07D277/56 , C07D277/82 , C07D401/12 , C07D409/12 , C07D417/12 , C07D487/04 , C07D498/04 , A61K31/5365
CPC分类号: C07D213/75 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/40 , C07D239/42 , C07D241/20 , C07D277/48 , C07D277/54 , C07D277/56 , C07D277/82 , C07D401/12 , C07D409/12 , C07D417/12 , C07D487/04
摘要: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.
摘要翻译: 本发明涉及式(I)化合物及其制备方法及其用途:其中:Ar为含氮杂芳环; X和Z各自为碳原子,等等; Y是CO,等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子,等等; 并且公式是单键或双键。 根据本发明,本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂,因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。
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