Biarylurea derivatives
    1.
    发明申请
    Biarylurea derivatives 失效
    双芳脲衍生物

    公开(公告)号:US20070027147A1

    公开(公告)日:2007-02-01

    申请号:US11002422

    申请日:2004-12-03

    摘要: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof: Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

    摘要翻译: 本发明涉及式(I)化合物及其制备方法及其用途:式(I)其中:Ar为含氮杂芳环; X和Z各自为碳原子,等等; Y是CO,等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子,等等; “img id =”custom-character-00001“he =”3.13mm“wi =”6.01mm“file =”US20070027147A1-20070201-P00001.TIF“alt =”custom character“img-content =”character“ img-format =“tif”/>是单键或双键。 根据本发明,本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂,因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。

    Biarylurea derivatives
    2.
    发明授权
    Biarylurea derivatives 失效
    双芳脲衍生物

    公开(公告)号:US07354946B2

    公开(公告)日:2008-04-08

    申请号:US11002422

    申请日:2004-12-03

    摘要: The present invention relates to a compound of Formula (I) and the manufacturing method(s) thereof and the use thereof:Formula (I) wherein: Ar is a nitrogen-containing heteroaromatic ring group; X and Z are each a carbon atom, and so on; Y is CO, and so on; R1 is a hydrogen atom, and so on; R2 and R3 are each a hydrogen atom, and so on; R4 and R5 are each a hydrogen atom, and so on; and the formula is a single bond or a double bond. According to the present invention, the compound of the present invention can provide Cdk4 and/or Cdk6 inhibitors for treating malignant tumors, because the compounds of the present invention exhibit a prominent growth inhibitory activity against tumor cells.

    摘要翻译: 本发明涉及式(I)化合物及其制备方法及其用途:式(I)其中:Ar为含氮杂芳环; X和Z各自为碳原子,等等; Y是CO,等等; R 1是氢原子等等; R 2和R 3各自为氢原子等; R 4和R 5各自为氢原子,等等; “img id =”CUSTOM-CHARACTER-00001“he =”3.13mm“wi =”6.01mm“file =”US07354946-20080408-​​P00001.TIF“alt =”自定义字符“img-content =”character“ img-format =“tif”/>是单键或双键。 根据本发明,本发明化合物可以提供用于治疗恶性肿瘤的Cdk4和/或Cdk6抑制剂,因为本发明的化合物对肿瘤细胞表现出显着的生长抑制活性。