发明授权
US07365178B2 Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
有权
酰基核苷酸探针及其合成方法，用于蛋白质组学分析
- 专利标题： Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
- 专利标题（中）： 酰基核苷酸探针及其合成方法，用于蛋白质组学分析
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申请号： US10817454申请日： 2004-04-01
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公开(公告)号： US07365178B2公开(公告)日： 2008-04-29
- 发明人: David Alan Campbell , Marek Liyanage , Anna Katrin Szardenings , Min Wu
- 申请人： David Alan Campbell , Marek Liyanage , Anna Katrin Szardenings , Min Wu
- 申请人地址： US CA La Jolla
- 专利权人： Activx Biosciences, Inc.
- 当前专利权人： Activx Biosciences, Inc.
- 当前专利权人地址： US CA La Jolla
- 代理机构： Foley & Lardner LLP
- 代理商 Stephen E. Reiter
- 主分类号： C07H21/02
- IPC分类号： C07H21/02 ; C07H21/00 ; C12Q1/68 ; G01N33/53 ; A61K38/00 ; C07K1/00
摘要：
The present invention provides tagged acyl phosphate probes (“TAPPs”), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, amount, or activity of target proteins in a complex protein mixture, preferably nucleotide binding proteins using nucleotide binding protein-directed TAPPs. The profiling methods described herein can have a number of steps leading to the identification of target nucleotide binding protein(s) in a complex protein mixture.