Invention Grant
- Patent Title: Constructs for delivery of therapeutic agents to neuronal cells
- Patent Title (中): 用于将治疗剂递送至神经元细胞的构建体
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Application No.: US10130973Application Date: 2000-12-04
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Publication No.: US07368532B2Publication Date: 2008-05-06
- Inventor: Clifford Charles Shone , John Mark Sutton , Nigel Silman
- Applicant: Clifford Charles Shone , John Mark Sutton , Nigel Silman
- Applicant Address: GB
- Assignee: Syntaxin Limited
- Current Assignee: Syntaxin Limited
- Current Assignee Address: GB
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C
- Priority: GB9928530.6 19991202; GB0008658.7 20000407
- International Application: PCT/GB00/04644 WO 20001204
- International Announcement: WO01/58936 WO 20010816
- Main IPC: C07K1/00
- IPC: C07K1/00 ; C07K14/10 ; C07K17/00 ; C07K14/00 ; C07K16/00
Abstract:
A non-toxic polypeptide, for delivery of a therapeutic agent to a neuronal cell, comprises a binding domain that binds to the neuronal cell, and a translocation domain that translocates the therapeutic agent into the neuronal cell, wherein the translocation domain is not a HN domain of a clostridial toxin and is not a fragment or derivative of a HN domain of a clostridial toxin.
Public/Granted literature
- US20030147895A1 Constructs for delivery of threrapeutic agents to neuronal cells Public/Granted day:2003-08-07
Information query
